PU-H71

1) Cat. No.: TRC-P840115; 2) Chemical Name: PU-H71 ; 3) CAS No.: 873436-91-0; 4) Mol. Formula: C18H21IN6O2S; 5) Mol. Weight: 512.37; 6) Packing Size: 10mg / 100mg; 7) Appearence: ; 8) Application Notes: PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Hsp90 plays a critical role in modulating the activity of many cell signaling proteins and are an attractive target for anti-cancer therapeutics. Studies indicate that Hsp90 inhibitors may serve as potential anti-Parkinson′s disease.; 9) Synonym: 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine;; 10) Solubility: ; 11) Storage condition: ; 12) References: Gewirth, D.T., et al.: J. Med. Chem., 49, 381 (2006), Taldone, T., et al.: Bioorh. Med. Chem., 17, 2225 (2009),