PF-3644022

1) Cat. No.: TRC-P293825; 2) Chemical Name: PF-3644022; 3) CAS No.: 1276121-88-0; 4) Mol. Formula: C21H18N4OS; 5) Mol. Weight: 374.46; 6) Packing Size: 10mg / 100mg; 7) Appearence: ; 8) Application Notes: PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. ; 9) Synonym: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one; ; 10) Solubility: ; 11) Storage condition: ; 12) References: Hegen, M., et al.: J. Immunol., 177, 1913 (2006), Anderson, D., et al.: J. Med. Chem., 50, 2647 (2007), Goldberg, D., et al.: Bioorg. Med. Chem. Lett., 18, 938 (2008), Burnette, B., et al.: Pharmacology, 84, 42 (2009), Mourey, et al.: J. Pharmacol. Exp. Ther., 333, 797 (2010),