Doramapimod

1) Cat. No.: TRC-D534250; 2) Chemical Name: Doramapimod ; 3) CAS No.: 285983-48-4; 4) Mol. Formula: C31H37N5O3; 5) Mol. Weight: 527.66; 6) Packing Size: 10mg / 100mg; 7) Appearence: Pale Beige Solid; 8) Application Notes: Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.; 9) Synonym: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea; BIRB 796BS; Birb 796;; 10) Solubility: DMSO, Methanol; 11) Storage condition: Refrigerator; 12) References: Pargellis, C. et al.: Nat. Struct. Biol., 9, 268 (2002,); Kuma, Y. et al.: J. Biol. CHem., 280, 19472 (2005); Yasui, H. et al.: Br. J. Haematol., 136, 414 (2007);