- 询价
- TRC
- 进口原装
- TRC-D230785
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Demecolcine
- 库存：
1
- 供应商：
甄准生物
- CAS号：
477-30-5
- 保存条件：
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- 规格：
10mg / 100mg
1) Cat. No.: TRC-D230785; 2) Chemical Name: Demecolcine; 3) CAS No.: 477-30-5; 4) Mol. Formula: C21H25NO5; 5) Mol. Weight: 371.43; 6) Packing Size: 10mg / 100mg; 7) Appearence: Yellow Solid; 8) Application Notes: An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.; 9) Synonym: (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; Deacetylmethylcolchicine; Colchamin; NSC 3096; Omain; Omaine; Reichstein's F; N-Desacetyl-N-methylcolchicine; Colcemid;; 10) Solubility: Dichlormethane, DMSO, Methanol; 11) Storage condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere; 12) References: Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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文献和实验相关实验
又称 demecolcine。是秋仙水碱的类缘生物碱。对于细胞具有与秋水仙碱同样的作用。因他的毒性远比秋水仙碱小，因此常被利用。
hyperphosphorylated H1 (pH1) from cells arrested in M phase by treatment with Colcemid (demecolcine; 0.06 µg/ml). The un‐ (Ac 0) and monoacetylated (Ac 1) isoforms of histone H4 are indicated. View Image
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Demecolcine
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