(R)-(+)-Blebbistatin

1) Cat. No.: TRC-B592495; 2) Chemical Name: (R)-(+)-Blebbistatin; 3) CAS No.: 1177356-70-5; 4) Mol. Formula: C18H16N2O2; 5) Mol. Weight: 292.33; 6) Packing Size: 5mg / 50mg; 7) Appearence: Bright Yellow Solid; 8) Application Notes: Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM. A negative control for the (S)-(-)-Blebblastatin. [a]D= +110 (c= 1.21 CHCl3) (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.; 9) Synonym: (3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one; (+)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one; (+)-Blebbistatin; ; 10) Solubility: Chloroform, Dichloromethane, DMSO, Ethyl Acetate, Methanol; 11) Storage condition: -20˚C Freezer; 12) References: Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)