6-Amino-4-(4-phenoxyphenylethy

1) Cat. No.: TRC-A621350; 2) Chemical Name: 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline; 3) CAS No.: 545380-34-5; 4) Mol. Formula: C22H20N4O; 5) Mol. Weight: 356.42; 6) Packing Size: 5mg / 10mg; 7) Appearence: Off-White to Pale Yellow Solid; 8) Application Notes: QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.; 9) Synonym: N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine; QNZ; ; 10) Solubility: DMSO, Methanol; 11) Storage condition: Refrigerator, Under Inert Atmosphere; 12) References: Tobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Choi, S., et al.: J. Biol. Chem., 281, 12722 (2006)