抗体 Anti-Ferritin Heavy Chain P

Production of Chimeric Heavy-Chain Antibodies

of fragment crystallizable (Fc), which is known to be crucial for a long serum half-life through binding to FcRn and antibody-mediated cell killing through binding to Fcγ receptors and complement. Single-domain antibodies (sdAbs) derived from camelid heavy

Introduction to Heavy Chain Antibodies and Derived Nanobodies

The immune response of infected or immunized dromedaries contains a diverse repertoire of conventional and heavy chain-only antibodies, both functional in antigen binding. By definition, a heavy chain antibody is devoid of a light chain

铁蛋白抗体技术 ferritin antibody technique

　　 为了在电镜下识别细胞及组织内的抗原部位而采用铁蛋白作标记的抗体的免疫细胞化学技术之一。铁蛋白是含有多量（约 20％）铁的结合蛋白，由直径约 10毫微米的蛋白质外壳及位于中心的直径 5.5毫微米的分子团组成。由于此分子团分成直径 3毫微米的 4个亚单位，在电镜下根据电子密度高的铁颗粒四角形排列是容易辨认其存在的。一般是将同铁蛋白结合的抗体（铁蛋白抗体）作用于先行固定的细胞后，制成超薄切片，用电镜观察。由于铁蛋白是大分子，具有不易透进细胞内这一难题。