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文献和实验Inhibition of Topo II function using poisons and catalytic inhibitors triggers checkpoints that act to delay progression of G2 cells into mitosis. Topo II poisons induce Topo II-associated DNA double-strand breaks that activate ATM
DNA Topoisomerase II-Catalyzed DNA Decatenation
catenated DNA duplexes found at the end of replication. The decatenation of DNA molecules is a topoisomerase II-specific reaction, and is a convenient assay for measuring topoisomerase II activity in vitro (1 ).
phosphatases modulates the activity, subcellular localization, or DNA/RNA/protein binding properties of numerous proteins. Indeed, it appears that the majority of intracellular proteins in human cells are phosphorylated to some degree under certain conditions
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