FcRn binding kit

Fc Engineering: Serum Half-Life Modulation Through FcRn Binding

Controlling the half-life of pharmaceuticals through Fc engineering is a desirable approach to achieve optimal exposure and targeting. The long serum residence time of gamma immunoglobulins is attributed to the Fc binding to the neonatal Fc

Methods to Engineer and Identify IgG1 Variants with Improved FcRn Binding or Effector Function

through interaction with complement and Fcγ receptors. Engineering the Fc portion to increase half-life through stronger binding to FcRn, or to increase complement or cell-mediated killing may lead to improved therapeutic antibodies. These improvements may benefit

Engineering of the Fc Region for Improved PK (FcRn Interaction)

proteins with altered in vivo pharmacokinetics through introduction of specific mutations in the antibody Fc region. Included are also protocols for evaluation of binding to the FcRn in vitro and determination of serum half-life through radioiodinating