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- TP750001
- 2026年09月14日
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- 文献和实验
- 技术资料
- 库存：
现货
- 英文名：
FGF1 (NM_000800) Human Recombinant Protein
- 供应商：
OriGene
- 规格：
100 ug
一、产品信息
| Product Data | |
| Description | Recombinant protein of human Fibroblast Growth Factor-acidic (FGF1) produced in E. coli |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence |
Protein Sequence (show)
|
| Tag | Tag Free |
| Predicted MW | 15.9 kDa |
| Concentration | Resuspend the protein to the desired concentration in proper buffer. |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a sterile solution containing 50 mM Tris-HCl, pH 7.5, 150 mM NaCl |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage Condition | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Bioactivity | Measured in a cell proliferation assay using 3T3 cells. ED50 for this effect is typically 0.031 - 0.046 ng/ml. |
| Endotoxin | < 0.1 EU per 1 µg of the protein by the LAL |
| Reference Data | |
| RefSeq | NP_000791 |
| Locus ID | 2246 |
| UniProt ID | P05230 |
| RefSeq Size | 4162 |
| Cytogenetics | 5q31.3 |
| RefSeq ORF | 465 |
| Synonyms | AFGF; ECGF; ECGF-beta; ECGFA; ECGFB; FGF-1; FGF-alpha; FGFA; GLIO703; HBGF-1; HBGF1 |
| Summary | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009] |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton |
二、活性测试数据
Measured in a cell proliferation assay using 3T3 fibroblast cells. The ED50 for this effect is 0.1~0.3 ng/mL in the presence of 10 µg/mL of heparin
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文献和实验，而人源细胞生产的白介素4活性保持不变，具有很好的稳定性，避免多次重复添加。 人源细胞表达技术 相比低等细菌等宿主而言，人源细胞表达技术生产高活性的重组细胞因子具有诸多优势。但是，人源细胞表达生产细胞因子产量低、成本较高。因此，如果突破人源细胞表达技术瓶颈，显著提高表达量，降低生产成本成为关键。 随着新型技术的不断出现，目前多种细胞因子已经采用高等人源细胞成功的表达，实现高活性细胞因子的规模化生产。例如ACROBiosystems USA 公司率先推出
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