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Anti-Alpha-synuclein (phospho

S129) 抗体

价格￥3815

品牌Abcam
货号ab59264
更新日期2026年08月31日

宿主Rabbit
适应物种Mouse, Human

2 年钻石会员

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human SNCA phospho S129. The exact immunogen used to generate this antibody is proprietary information.

P37840

特异性

Detects endogenous levels of Synuclein only when phosphorylated at serine 129. Due to 69% sequence homology ab59264 might react with Beta synuclein.

反应性数据HTML：

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "

Antigen retrieval: Microwave method - put the slice into 10 mmol/L citrate buffer (pH 6.0), microwave high temperature for 5 minutes, and then medium temperature for 15 minutes.

Primary antibody incubation: 1 hour at 37°C.

Secondary antibody: Poly-HRP-Anti Mouse/Rabbit IgG, 50 μL for 30 minutes.

DAB reagent.

" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "

Please see WB protocol details in the image legend.

", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

产品用途HTML：

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

产品详情HTML：

产品详情

What is this antibody validated in?
Anti-Alpha-synuclein (phospho S129) antibody (ab59264) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse samples.

Trusted by the scientific community
Anti-Alpha-synuclein (phospho S129) (ab59264) was first used in a scientific publication in 2007 and has been cited over 60 times in peer-reviewed journals.

性能和储存信息HTML：

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

靶点信息HTML：

靶点信息

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed : 20798282, PubMed : 26442590, PubMed : 28288128, PubMed : 30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed : 28288128, PubMed : 30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed : 30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed : 20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed : 20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed : 26442590).

See full target information SNCA phospho S129

文献1：Molecular neurodegeneration 20:26 PubMed40038767 2025

文献2：Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species.

文献3：Mª Salomé Sirerol-Piquer,Ana Perez-Villalba,Pere Duart-Abadia,Germán Belenguer,Ulises Gómez-Pinedo,Laura Blasco-Chamarro,Pau Carrillo-Barberà,Azucena Pérez-Cañamás,Victoria Navarro-Garrido,Benjamin Dehay,Miquel Vila,Javier Vitorica,Francisco Pérez-Sánchez,Isabel Fariñas

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【求助】抗体制备服务
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关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性