Recombinant Cyclin D1 Antibody

类别: Antibodies

产品子类型: Primary Antibody

描述: Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

克隆号: rCCND1/4752

应用稀释比例: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Western blot: 2-4ug/ml

应用说明: Optimal dilution of the recombinant Cyclin D1 antibody should be determined by the researcher.

免疫原: A portion of amino acids 200-295 from the human protein was used as the immunogen for the recombinant Cyclin D1 antibody.

防腐剂: 1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

纯化方法: Protein G affinity chromatography

UniProt ID: P24385

保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

备注: For research use only.