Ubiquitin Antibody 抗体，orb26413

类别: Antibodies

产品子类型: Primary Antibody

描述: Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease etc.

克隆号: UBB/2122

应用稀释比例: ELISA (order BSA/sodium azide-free format for coating),Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

应用说明: Optimal dilution of the Ubiquitin antibody should be determined by the researcher.

免疫原: A portion of amino acids 1-119 from the human protein was used as the immunogen for the Ubiquitin antibody.

防腐剂: 1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

纯化方法: Protein G affinity chromatography

UniProt ID: P62988, P62987, P0CG47, P62979, P0CG48

保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

备注: For research use only.