- ￥8775
- Biorbyt
- orb2641315
- 英国
- 2026年08月07日
- FACS, IHC-P
- Mouse
- Human
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- 文献和实验
- 技术资料
- 抗体名：
STAT6 Antibody 抗体
- 抗体英文名：
STAT6 Antibody
- 应用范围：
FACS, IHC-P
- 宿主：
Mouse
- 适应物种：
Human
- 保质期：
12 months from date of receipt.
- 抗原来源：
详询
- 目录编号：
orb2641315
- 级别：
科研
- 库存：
99
- 供应商：
Biorbyt
- 标记物：
Unconjugated
- 克隆性：
Monoclonal
- 保存条件：
详询
- 亚型：
Mouse IgG1, kappa
- 免疫原：
详询
- 规格：
100 ug
类别: Antibodies
产品子类型: Primary Antibody
描述: STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity.
克隆号: STAT6/2410
应用稀释比例: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Flow cytometry: 1-2ug/million cells
应用说明: Optimal dilution of the STAT6 antibody should be determined by the researcher.
免疫原: Full length recombinant human protein was used as the immunogen for this STAT6 antibody.
防腐剂: 1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
纯化方法: Protein G affinity chromatography
研究领域: Cancer Biology
UniProt ID: P42226
保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
备注: For research use only.
产品子类型: Primary Antibody
描述: STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity.
克隆号: STAT6/2410
应用稀释比例: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Flow cytometry: 1-2ug/million cells
应用说明: Optimal dilution of the STAT6 antibody should be determined by the researcher.
免疫原: Full length recombinant human protein was used as the immunogen for this STAT6 antibody.
防腐剂: 1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
纯化方法: Protein G affinity chromatography
研究领域: Cancer Biology
UniProt ID: P42226
保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
备注: For research use only.
IHC staining of FFPE human renal cell carcinoma with STAT3 antibody (clone STAT6/2410). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Analysis of HuProt (TM) microarray containing more than 19, 000 full-length human proteins using STAT6 antibody (clone STAT6/2410). These results demonstrate the foremost specificity of the STAT6/2410 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free STAT6 antibody (clone STAT6/2410) as confirmation of integrity and purity.
IHC staining of FFPE human liposarcoma tissue with STAT3 antibody (clone STAT6/2410). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Flow cytometry staining of PFA-fixed human HeLa cells with STAT6 antibody; Red = isotype control, Blue = STAT6 antibody.
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/DAMPs，包括C型凝集素（如甘露糖受体抓取病原体表面糖分子）、清道夫受体（识别LPS或凋亡细胞露出的磷脂酰丝氨酸）及部分Toll样受体。 ·调理素受体：当调理素（抗体（IgG）或补体分子）先给目标“贴上标签”后，巨噬细胞便会派出调理素受体（Fcγ受体和补体受体（CRs））结合标签，高效触发吞噬。 这些受体并非单打独斗，而是协同招募、聚集成簇，确保精准锁定“敌人”与“垃圾”，为后续吞食和消化铺平道路。 图2. 巨噬细胞的识别机制[1] 2、吞食 识别后，一系列信号途径被激活，形成吞噬杯、伪足和吞噬
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STAT6 Antibody 抗体，orb2641315，Biorbyt
￥8775
