POLE3 Antibody / CHRAC17 抗体，or

类别: Antibodies

产品子类型: Primary Antibody

描述: DNA replication is initiated by the binding of initiation factors to the origin of replication. Nucleosomes inhibit access to the replication machinery at these origin sequences. Nucleosome remodeling factors increase the accessibility of nucleosomal DNA to transcriptional regulators. CHRAC15 and CHRAC17 are subunits of the nucleosomal remodeling factor CHRAC (chromatin accessibility complex), which increases the accessibility of nucleosomal DNA in an ATP-dependent manner. Unlike other known chromatin remodeling factors, CHRAC also functions during chromatin assembly by using ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. This conversion process occurs when CHRAC organizes randomly deposited histones into a regularly spaced array. In the presence of CHRAC, the nucleosomal ATPase ISWI catalyzes several ATP-dependent transitions of chromatin structure.

克隆号: PCRP-POLE3-2F10

应用稀释比例: Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml

应用说明: Optimal dilution of the POLE3 antibody should be determined by the researcher.

免疫原: Recombinant full-length human DNA polymerase epsilon subunit 3 protein was used as the immunogen for the POLE3 antibody.

防腐剂: 1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

纯化方法: Protein A/G affinity

研究领域: Epigenetics & Chromatin

UniProt ID: Q9NRF9

保存条件: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

备注: For research use only.