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- 文献和实验
- 技术资料
- 保存条件：
2-8度
- 保质期：
1年
- 英文名：
MECP2
- 库存：
999
- 供应商：
上海淳麦生物
- 规格：
/5ug/20ug/1mg
Recombinant Human Methyl CpG Binding Protein 2
英文简称:
MECP2
中文名称:
重组人甲基化CpG结合蛋白2
背景资料:
MECP2 is the key modificator of eukaryotic genomes and has a crucial part in mammalian development. Human proteins MECP2， MBD1， MBD2， MBD3， and MBD4 form a family of nuclear proteins linked by the existence in each of a methyl-CpG binding domain （MBD）. Each one of these proteins， with the exception of MBD3， can bind specifically to methylated DNA. In addition， MECP2， MBD1 and MBD2 can inhibit transcription from methylated gene promoters. Unlike other MBD family members， MECP2 is X-linked and subject to X inactivation. MECP2 is expendable in stem cells， but is vital for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome， a progressive neurologic developmental disorder and one of the most common reasons of mental retardation in females.
产品描述:
MECP2 Human Recombinant is expressed in 293 cells. The protein containing 486 amino acids （1-486a.a.） fused to an N-terminal Flag tag， having an Mw of 53.56kDa.
来源宿主:
人胚肾HEK细胞重组表达
溶解建议:
提供的重组人甲基化CpG结合蛋白2产品形式为经无菌过滤处理的无色溶液.
保存建议：
重组人甲基化CpG结合蛋白2产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.产品若长期保存，建议添加载体蛋白（0.1% HSA或BSA）.避免反复冻融.
应用领域：
重组人甲基化CpG结合蛋白2产品可广泛应用于功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词：
重组人甲基化CpG结合蛋白2、Recombinant Human Methyl CpG Binding Protein 2、MECP2、重组蛋白、哺乳细胞表达、标签蛋白、CMBIO、淳麦生物
其他简介：
CMBIO
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文献和实验Purification of MeCP2-Containing Deacetylase from Xenopus laevis
that requires at least 12 symmetrical methyl-CpGs for DNA binding (6 ). MeCP2 is a single polypeptide containing a methyl-binding domain capable of binding a single methyl-CpG, and a transcriptional repression domain (8 ). Recently MeCP2 was shown to interact
MECP2的突变可以导致持续性神经系统退化（neurodegenerative disorder）Rett综合症。这个x-染色体相关综合症（X-linked syndrome）主要在女性身上体现，但相对温和的突变也可以导致男性的智力障碍(mental retardation)。 （Figure 1： Pedigrees of the four families (L36, S49, T33, and T
Purification of the MeCP2/Histone Deacetylase Complex from Xenopus laevis
repression (6 ,7 ). MeCP1 is a relatively uncharacterized complex that requires at least 12 symmetrical methyl-CpGs for DNA binding (6). MeCP2 is a single polypeptide containing a methyl-binding domain capable of binding a single methyl-CpG
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