重组人凝血因子III(Tissue Factor)

产品英文名称：
Recombinant Human Coagulation Factor III

英文简称:
Tissue Factor

中文名称:
重组人凝血因子III

背景资料:
Tissue factor is well-known as the main cellular initiator of blood coagulation. The Tissue factor gene encodes coagulation factor III which is a cell surface glycoprotein that enables cells to initiate the blood coagulation cascades， and functions as the high-a大肠杆菌中重组表达inity receptor for the coagulation factor VII. Following vessel injury， the Tissue Factor and Factor VIIa complex activates the coagulation protease cascade， which leads to fibrin deposition and activation of platelets. The ensuing complex presents a catalytic event， which is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Therefore， Tissue factor has a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Tissue Factor can also be stimulated by the inflammatory mediators interleukin 1 and TNF， as well as by endotoxin， to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not bTissue factor Human Recombinant produced in E.Coli is single， a non-glycosylated， Polypeptide chain containing 219 amino acids of the extracellular domain （33-251） having a molecular mass of 29.39 kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The Tissue factor is purified by proprietary chromatographic techniques.n described. Certain levels of Tissue Factor are essential for the maintained viability and growth of endothelium and Tissue Factor-expressing tumor cells. Additionally， abnormal Tissue Factor expression inside the vasculature initiates life threatening thrombosis in various diseases， for example sepsis， atherosclerosis， and cancer. Alternative spliced Tissue Factor expression advances tumor growth， and is linked to increased tumor cell proliferation and angiogenesis in pancreatic cancer.

产品描述:
Tissue factor Human Recombinant produced in E.Coli is single， a non-glycosylated， Polypeptide chain containing 219 amino acids of the extracellular domain （33-251） having a molecular mass of 29.39 kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The Tissue factor is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

溶解建议:
Sterile Filtered clear solution. Tissue factor protein is supplied in 22mM Tris.HCl pH8.0， 1mM EDTA and 50% glycerol.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. Please avoid freeze thaw cycles.
应用领域：
重组人凝血因子III产品可广泛应用于免疫调节研究、炎症研究、信号传导研究、药物靶点研究、毒理学研究、功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。

关键词：
重组人凝血因子III、Recombinant Human Coagulation Factor III、Tissue Factor、重组蛋白、多肽、白介素、受体蛋白、毒素

其他简介：

 
CMBIO