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- 文献和实验
- 技术资料
- 保存条件:
2-8度
- 保质期:
1年
- 英文名:
TNFR1 His
- 库存:
999
- 供应商:
上海淳麦生物
- 规格:
/5ug/20ug/1mg
Recombinant Human Tumor Necrosis Factor Receptor Type 1,His Tag
英文简称:
TNFR1 His
中文名称:
重组人1型肿瘤坏死因子受体,His标签
背景资料:
TNFR1 belongs to the TNF-receptor superfamily. TNFR1 is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II,which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors s人1型肿瘤坏死因子受体,His标签重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有161个氨基酸片段(41-201),在其氨基末端融合了一个分子量为4.5kDa的6xHis标签,分子量为22.68kDa.该人1型肿瘤坏死因子受体,His标签重组蛋白最终由标准的色谱技术纯化出.m to increase as a result of shedding of the extracellular domains of the membrane bound receptors. TNF-a,TNFR1 and TNFR2 have roles in cellular di大肠杆菌中重组表达erentiation. TNFR1 and TNFR2 function in cell type-specific renal injury. TNFR1 is capable of signaling both cell survival and apoptosis. TNFR1-induced apoptosis requires 2 sequential signaling complexes. TNFR1 is capable of activating NF-kappaB,mediate apoptosis,and function as a regulator of inflammation. Oxidative stress promotes TNFR1 and TNFR2 self-interaction,ligand-independent and enhanced ligand-dependent TNF signaling. TNFR1 contributes to the induction of non-cytocidal TNF e大肠杆菌中重组表达ects including anti-viral state and activation of the acid sphingomyelinase. Human TNFR1 has a major region which controls cell surface expression. High levels of soluble TNF receptors are found in the amniotic fluid of pregnant women. Germline mutations of the extracellular domains of TNFR1 are linked to the autosomal dominant periodic fever syndrome. The impaired receptor clearance is believed to be a mechanism of the disease. Familial hibernian fever (FHF) is caused by defects in TNFRSF1A gene.
产品描述:
人1型肿瘤坏死因子受体,His标签重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有161个氨基酸片段(41-201),在其氨基末端融合了一个分子量为4.5kDa的6xHis标签,分子量为22.68kDa.该人1型肿瘤坏死因子受体,His标签重组蛋白最终由标准的色谱技术纯化出.
来源宿主:
大肠杆菌中重组表达
溶解建议:
提供的人1型肿瘤坏死因子受体,His标签(TNFR1 His)产品为过滤灭菌的透明溶液;其中人1型肿瘤坏死因子受体,His标签(TNFR1 His)产品溶解于1x PBS,50%甘油溶液中.
保存建议:
人1型肿瘤坏死因子受体,His标签(TNFR1 His)溶液可以在4℃冷藏保存2-4周时间;如果想延长保存时间,建议分装后置于-20℃冻存.请避免反复冻融.
应用领域:
重组人1型肿瘤坏死因子受体,His标签产品可广泛应用于信号传导研究、药物靶点研究、毒理学研究、功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词:
重组人1型肿瘤坏死因子受体,His标签、Recombinant Human Tumor Necrosis Factor Receptor Type 1,His Tag、TNFR1 His、重组蛋白、多肽、受体蛋白、毒素、原核表达
其他简介:
CMBIO




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文献和实验TRAF‐Mediated TNFR‐Family Signaling
Keywords: TNF family; TNFR family; IL?1R/TLR; TRAF proteins; signal transduction; inflammation GO TO THE FULL PROTOCOL: PDF or HTML at Wiley Online Library
Genetic Engineering in the Mouse: Tuning TNF/TNFR Expression
With the exponential increase in the number of genes identified by various genome projects, it has become imperative that efficient methods be developed for deciphering gene function. Genetically engineered strains of mice are now critical
(3)干扰素受体家族(IFNR―F):也称Ⅱ型细胞因子受体家族,包括IFN-αBR、IFN-α/βR、IFN-γR和IL-10R。该家族受体分子的胞膜外区含有2―4个FNⅢ结构域。IFN―αBR只能结合IFN-α的IFN-α8,IFNa/βR能结合IFN-α和IFN-β。这两种受体至少含有一条多肽链,人类IFN-α/βR是一个二硫键连接的同源二聚体。有生物学活性的IFN-γR至少含有。和日链两条多肽链,每条链含有两个FN3结构域。 (4)肿瘤坏死因子受体家族(TNFR―F):包括TNFR
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