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- 文献和实验
- 技术资料
- 免疫原:
inquire
- 亚型:
Human IgG1 - kappa
- 形态:
Powder
- 保存条件:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized antibodies are shipped at ambient temperature.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 级别:
Research use only
- 库存:
In Stock
- 供应商:
缔码生物(武汉)科技有限公司
- 宿主:
Humanized
- 应用范围:
ELISA, Flow Cyt
- 浓度:
详见COA
- 靶点:
EGFR
- 抗体英文名:
Anti-EGFR(QD6 biosimilar) mAb
- 抗体名:
Anti-EGFR(QD6 biosimilar) mAb
- 规格:
50μg
| 产品类型 | Biosimilar reference antibodies |
|---|---|
| 靶点 | EGFR |
| Uniprot ID | P00533 |
| 背景 | Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals. |
| 通用名 | QD6,AZD9592 without cMet mAb |
| 货期 | In Stock |
| 产品英文名称 | Anti-EGFR(QD6 biosimilar) mAb |
| 内毒素 | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| 保质期 | 12 months from date of dispatch |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized antibodies are shipped at ambient temperature. |
| 别名 | ERBB; ERBB1; HER1 |
| 应用 | ELISA, Flow Cyt |
| 有无偶联 | Unconjugated |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 宿主种属 | Humanized |
| IgG亚型 | Human IgG1 - kappa |
| 反应种属 | Human |
| 推荐稀释比 | ELISA 1:5000-10000, Flow Cyt 1:100 |
| 应用范围 | Research use only |

Figure 1. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Human EGFR Protein, His Tag (PME100099) can bind Anti-EGFR(QD6 biosimilar) mAb (BME100250) in a linear range of 0.13–16 ng/mL.

Figure 2. Flow cytometry analysis with 15μg/mL Anti-EGFR(QD6 biosimilar) mAb (BME100250) on HEK293 cells transfected with Human EGFR protein (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram), and isotype antibody on HEK293 transfected with irrelevant protein (Orange histogram).
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仍超过 50 亿美元。 图七 Journal of Biomedical Science (2020) 27:1来自抗体协会 (Antibody Society) 的数据显示,临床管道中也存在类似的大量内卷现象。目前有将近 870 种抗体在临床开发中,但其中大约 36% 的抗体集中在下表二的 10 个靶点中。PD1/PDL1、HER2、CTLA4、EGFR 和 CD20 仍然占据较高的比例。 表二:Nature Reviews Drug Discovery 20, 10 (2021)癌症将继续占据
本文已发表于中国肿瘤生物治疗杂志.2003,10(3):221-222.【摘要】表皮生长因子受体(Epidermal Growth Factor Receptor EGFR)是原癌基因c-erb-B1的表达产物。其过表达和突变体均与肿瘤发生发展有密切关系,基于此优点成为目前肿瘤治疗的新靶点。本文就EGFR与肿瘤的关系及其单抗治疗肿瘤的进展作一综述。【关键词】表皮生长因子受体(EGFR),单克隆抗体,肿瘤治疗【中图分类号】R730.5 [文献标识码] AEGFR monocolonal
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