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- 文献和实验
- 技术资料
- 免疫原:
inquire
- 亚型:
Human IgG1 - kappa
- 形态:
Powder
- 保存条件:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 级别:
Research use only
- 库存:
In Stock
- 供应商:
缔码生物(武汉)科技有限公司
- 宿主:
Homo sapiens
- 应用范围:
Flow Cyt
- 浓度:
详见COA
- 靶点:
B7-H4
- 抗体英文名:
Anti-B7-H4(SGN-B7H4V biosimilar) mAb
- 抗体名:
Anti-B7-H4(SGN-B7H4V biosimilar) mAb
- 规格:
50μg
| 产品类型 | Biosimilar reference antibodies |
|---|---|
| 靶点 | B7-H4 |
| Uniprot ID | Q7Z7D3 |
| 背景 | Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals. Our unconjugated biosimilar monoclonal antibodies (mAbs) are based on the sequences outlined in relevant patents or scientific publications. These antibodies are in their native, unconjugated form, meaning they do not contain any payload or therapeutic agent attached. They are designed for use in research and development, and their performance has been tested as standalone molecules through comprehensive QC tests. |
| 通用名 | SGNB7H4V,SGN-B7H4V,SGNB 7H4V, Unconjugated mAb |
| 货期 | In Stock |
| 产品英文名称 | Anti-B7-H4(SGN-B7H4V biosimilar) mAb |
| 内毒素 | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| 保质期 | 12 months from date of dispatch |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature. |
| 别名 | VTCN1 |
| 应用 | Flow Cyt |
| 有无偶联 | Unconjugated |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| 宿主种属 | Homo sapiens |
| IgG亚型 | Human IgG1 - kappa |
| 反应种属 | Human |
| 推荐稀释比 | Flow Cyt 1:100 |
| 应用范围 | Research use only |
Figure 1. Flow cytometry analysis with 1 μg/mL Anti-B7-H4(SGN-B7H4V biosimilar) mAb (BME100197) on HEK293 cells transfected with Human B7-H4 protein (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
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从免疫防线到促癌帮凶:Elabscience一文读懂肿瘤微环境中的巨噬细胞!
免疫应答: (1)表达PD-L1、B7-H4等免疫检查点分子,直接抑制T细胞功能; (2)分泌IL-10、TGF-β等免疫抑制性细胞因子; (3)表达精氨酸酶1(ARG1),耗竭肿瘤微环境中的L-Arg,导致T细胞受体表达下调; (4)通过CD47/SIRPα轴传递"不要吃我"信号,抑制巨噬细胞自身的吞噬活性。 4. 促进肿瘤干细胞维持和转移 TAMs通过分泌IL-10、TGF-β等因子维持肿瘤干细胞特性,促进上皮-间充质转化。在肺、肝、乳腺等肿瘤中,TAMs通过IL-6/STAT3、TGF-β/Smad等信号
(BTC) ELISA 48T/96T 2000/3000 进口分装 F00241 人B7-H4(B7-H4) ELISA 48T/96T 2000/3000 进口分装 F00242 b - 防御素 ( b -Defensin) ELISA 48T/96T 2000/3000 进口分装 F00300 CAE-Ab ELISA 96T 1200 进口分装 F00310 降钙素 (Calcitonin) ELISA 48T/96T 1500/2500 进口分装 F00320 P
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