GDF15(ponsegromab)参照抗体

产品类型	Biosimilar reference antibodies
靶点	GDF15
Uniprot ID	Q99988
背景	Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals.
通用名	PF-06946860
货期	In Stock
产品英文名称	Anti-GDF15(ponsegromab biosimilar) mAb
内毒素	Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization.
保质期	12 months from date of dispatch
无菌性	Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use.
储存与运输	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
别名	GDF-15;MIC-1;MIC1;NAG-1;PDF;PLAB;PTGFB
应用	ELISA, Flow Cyt
有无偶联	Unconjugated
组分	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
宿主种属	Humanized
IgG亚型	Human IgG1 - kappa
反应种属	Human
推荐稀释比	ELISA 1:5000-10000, Flow Cyt 1:100
应用范围	Research use only

Figure 1. Flow cytometry analysis under cell membrane permeable condition with 1 μg/mL Anti-GDF15 (ponsegromab biosimilar) mAb (BME100090) on HEK293 cells transfected with Human GDF15 protein (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).

Figure 2. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Human GDF15 Protein, hFc Tag (PME100628) can bind Anti-GDF15(ponsegromab biosimilar) mAb (BME100090) in a linear range of 0.64–80 ng/mL. In order to specifically detect BME100090, mouse anti-human Fab-specific antibody was used as detection antibody.