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- 文献和实验
- 技术资料
- 免疫原:
inquire
- 亚型:
Human IgG1 - kappa
- 形态:
Powder
- 保存条件:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 级别:
Research use only
- 库存:
In Stock
- 供应商:
缔码生物(武汉)科技有限公司
- 宿主:
Homo sapiens
- 应用范围:
ELISA; Flow Cyt
- 浓度:
详见COA
- 靶点:
B7H4
- 抗体英文名:
Anti-B7-H4(alsevalimab biosimilar) mAb
- 抗体名:
Anti-B7-H4(alsevalimab biosimilar) mAb
- 规格:
50μg
| 产品类型 | Biosimilar reference antibodies |
|---|---|
| 靶点 | B7H4 |
| Uniprot ID | Q7Z7D3 |
| 背景 | Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals. |
| 通用名 | FPA-150, FPA150 |
| 货期 | In Stock |
| 产品英文名称 | Anti-B7-H4(alsevalimab biosimilar) mAb |
| 内毒素 | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| 保质期 | 12 months from date of dispatch |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | B7-H4;B7h.5;B7H4;B7S1;B7X;PRO1291;VCTN1 |
| 应用 | ELISA; Flow Cyt |
| 有无偶联 | Unconjugated |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 宿主种属 | Homo sapiens |
| IgG亚型 | Human IgG1 - kappa |
| 反应种属 | Human |
| 推荐稀释比 | ELISA 1:5000-10000; Flow Cyt 1:100 |
| 应用范围 | Research use only |
Figure 1. ELISA plate pre-coated by 1 μg/ml (100 μL/well) Human B7-H4, hFc-His tagged protein (PME100053) can bind Anti-B7-H4 Neutralizing antibody (BME100078) in a linear range of 3.2-80 ng/ml. In order to specifically detect BME100078, mouse anti-human Fab-specific antibody was used as detection antibody.
Figure 2. Flow cytometry analysis with 1 μg/mL Anti-B7-H4 (alsevalimab) mAb (BME100078) on HEK293 cells transfected with Human B7-H4 protein (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
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从免疫防线到促癌帮凶:Elabscience一文读懂肿瘤微环境中的巨噬细胞!
免疫应答: (1)表达PD-L1、B7-H4等免疫检查点分子,直接抑制T细胞功能; (2)分泌IL-10、TGF-β等免疫抑制性细胞因子; (3)表达精氨酸酶1(ARG1),耗竭肿瘤微环境中的L-Arg,导致T细胞受体表达下调; (4)通过CD47/SIRPα轴传递"不要吃我"信号,抑制巨噬细胞自身的吞噬活性。 4. 促进肿瘤干细胞维持和转移 TAMs通过分泌IL-10、TGF-β等因子维持肿瘤干细胞特性,促进上皮-间充质转化。在肺、肝、乳腺等肿瘤中,TAMs通过IL-6/STAT3、TGF-β/Smad等信号
(BTC) ELISA 48T/96T 2000/3000 进口分装 F00241 人B7-H4(B7-H4) ELISA 48T/96T 2000/3000 进口分装 F00242 b - 防御素 ( b -Defensin) ELISA 48T/96T 2000/3000 进口分装 F00300 CAE-Ab ELISA 96T 1200 进口分装 F00310 降钙素 (Calcitonin) ELISA 48T/96T 1500/2500 进口分装 F00320 P
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