- ￥800
- DIMA BIOTECH/缔码生物
- 武汉
- BME100018
- 2026年07月10日
- ELISA; Flow Cyt
- Homo sapiens
- Human
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- 文献和实验
- 技术资料
- 免疫原：
inquire
- 亚型：
Human IgG1 - kappa
- 形态：
Powder
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 级别：
Research use only
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Homo sapiens
- 应用范围：
ELISA; Flow Cyt
- 浓度：
详见COA
- 靶点：
CD27
- 抗体英文名：
Anti-CD27 (varlilumab biosimilar) mAb
- 抗体名：
Anti-CD27 (varlilumab biosimilar) mAb
- 规格：
50μg
| 产品类型 | Biosimilar reference antibodies |
|---|---|
| 靶点 | CD27 |
| Uniprot ID | P26842 |
| 背景 | Research grade biosimilar. Not for use in therapeutic or diagnostic procedures for humans or animals. |
| 通用名 | 1F5, CDX-1127 |
| 货期 | In Stock |
| 产品英文名称 | Anti-CD27 (varlilumab biosimilar) mAb |
| 内毒素 | Less than 1.0 EU/μg by the LAL method. For <1 EU/mg requirements, please contact us for customization. |
| 保质期 | 12 months from date of dispatch |
| 无菌性 | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | CD27;TNFRSF7;S152;T14;Tp55 |
| 应用 | ELISA; Flow Cyt |
| 有无偶联 | Unconjugated |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 宿主种属 | Homo sapiens |
| IgG亚型 | Human IgG1 - kappa |
| 反应种属 | Human |
| 推荐稀释比 | ELISA 1:5000-10000; Flow Cyt 1:100 |
| 应用范围 | Research use only |
Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μL/well) Human CD27, hFc tagged protein (PME100475) can bind Anti-CD27 Neutralizing antibody in a linear range of 3.2-80.0 ng/ml. In order to specifically detect BME100018, mouse anti-human Fab-specific antibody was used as detection antibody.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CD27, mFc-His tagged protein ([getskuurl sku="PME100013"]) can bind Anti-CD27 Neutralizing antibody in a linear range of 0.64-16.0 ng/ml.
Figure 3. HEK293 cell line transfected with irrelevant protein (B) and human CD27 protein (A) were surface stained with anti-CD27 neutralizing antibody 1μg/ml (varlilumab) followed by Alexa 488-conjugated anti-human IgG secondary antibody.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验CD27 分子 CD27 常用单克隆抗体或代号： VIT14,S152,OKT18A 主要表达细胞： T, Bsub [T] 分子质量(kDa)和结构： p55(TNFR- SF)(同源二聚体) 功 能： CD70的配体,T细胞活化增殖 CD27 Marker of T cell activation CD27/CD70 interactions also regulate
Nature Medicine 再论多重免疫荧光揭示预测性生物标志物，用于优化免疫治疗临床试验设计
同时检测（1）细胞毒性 T 细胞（CD8 和自然杀伤细胞）、Treg 细胞（CD8+、GzmA+ 、CD4+、FOXP3+/CD56+)（2） B 细胞、PC 和成纤维细胞（MUM1+、CD20+、CD27+、CD3+、COL1A1+、IgG+）（3）激活、常规 DCs 和巨噬细胞（HLA-DR、CD11c、CD1c、CD68、CD83）。对患者样本分析发现，表达 IgG 的 PC 与患者结果之间的关联表明抗肿瘤抗体的产生，这可能通过 DC 增加抗原呈递来改善 CD8 T 细胞反应。CD
CD70 分子 CD70 常用单克隆抗体或代号： Ki- 24;(CD27L) 主要表达细胞： Tsub,Ba,RS [NL] 分子质量(kDa)和结构： gp55,75,95,110,170 功 能： CD27的配体,淋巴细胞活化 CD70 Aka CD27 ligand Role in T cell activation; induces T cell
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