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- 技术资料
- CAS号：
1125758-85-1
- 规格：
1mg/1mLx10mM(inDMSO)/2mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥204.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥392.0 |
| 规格： | 2mg | 产品价格： | ￥271.0 |
| 规格： | 5mg | 产品价格： | ￥364.0 |
| 规格： | 10mg | 产品价格： | ￥551.0 |
| 规格： | 25mg | 产品价格： | ￥1104.0 |
| 规格： | 50mg | 产品价格： | ￥1824.0 |
| 规格： | 100mg | 产品价格： | ￥2864.0 |
Product Introduction
Bioactivity
| 名称 | A-804598 |
| 描述 | A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human). |
| 体外活性 | A-804598 effectively blocked IL-1β release in the THP-1 cells (IC50: 8.5 nM). It also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50: 8.1 nM) with similar potency as in the calcium-influx assay. [1] |
| 体内活性 | According to the autoradiographic analysis of coronal rat brain sections, there was specific binding of [3H]-A-804598 throughout the rat brain. In the grey matter of the L4-L6 region of the rat spinal cord, it was also found that high levels of [3H]-A-804598 specific binding. [2] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 31.5 mg/mL (99.88 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.34 mM), Sonication is recommended. |
| 关键字 | P2XRs | P2XReceptor | P2X7 | P2X Receptor | Inhibitor | inhibit | A-804598 | A804598 |
| 相关产品 | Oxatomide | Lappaconitine | (E/Z)-Sivopixant | NP-1815-PX | ATP disodium salt | Gefapixant citrate | PSB-12062 | Ivermectin | Eperisone hydrochloride | Paroxetine | Sodium metatungstate | Aurintricarboxylic acid |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Neurotransmitter Receptor Compound Library | Neuronal Signaling Compound Library | NO PAINS Compound Library | Ion Channel Targeted Library | Membrane Protein-targeted Compound Library | Target-Focused Phenotypic Screening Library |
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化合物 A804598【1125758-85-1】
￥204 - 2864
