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- CAS号:
29094-61-9
- 规格:
1mLx10mM(inDMSO)/1g/50mg/100mg/500mg
| 规格: | 1mLx10mM(inDMSO) | 产品价格: | ¥134.0 |
|---|---|---|---|
| 规格: | 1g | 产品价格: | ¥470.0 |
| 规格: | 50mg | 产品价格: | ¥158.0 |
| 规格: | 100mg | 产品价格: | ¥213.0 |
| 规格: | 500mg | 产品价格: | ¥330.0 |
Product Introduction
Bioactivity
| 名称 | Glipizide |
| 描述 | Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity. |
| 激酶实验 | The activity of caspase-3, -8 and -9 is assessed using the caspase-3, -8 and -9 colorimetric assay kits, respectively. In brief, 1×106?cells in a 60-mm culture dish are incubated with 10 mM Valproic acid for 24 h. The cells are then washed in PBS and suspended in 5 volumes of lysis buffer provided with the kit. Protein concentrations are determined using the Bradford method. Supernatants containing 50 μg total protein are used to determine caspase-3, -8 and -9 activities. The supernatants are added to each well in 96-well microtiter plates with DEVD-pNA, IETD-pNA or LEHD-pNA as caspase-3, -8 and -9 substrates and the plates are incubated at 37°C for 1 h. The optical density of each well is measured at 405 nm using a microplate reader. The activity of caspase-3, -8 and -9 is expressed in arbitrary absorbance units. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 82 mg/mL (184.05 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+90% Corn Oil : 3.3 mg/mL (7.41 mM), Sonication is recommended. |
| 关键字 | type 2 diabetes | sulfonylurea class | PPARγ | PotassiumChannel | Potassium Channel | pancreatic β | mellitus | KcsA | K-4024 | K4024 | K ATP | Inhibitor | inhibit | Glipizide | CP-28720 | CP28720 | ATP-sensitive potassium | ABCC |
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