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- TargetMol
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- 2026年07月07日
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- 详细信息
- 文献和实验
- 技术资料
- CAS号：
331770-21-9
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mg | 产品价格： | ￥380.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥856.0 |
| 规格： | 5mg | 产品价格： | ￥944.0 |
| 规格： | 10mg | 产品价格： | ￥1416.0 |
| 规格： | 25mg | 产品价格： | ￥2600.0 |
| 规格： | 50mg | 产品价格： | ￥3824.0 |
| 规格： | 100mg | 产品价格： | ￥5184.0 |
| 规格： | 200mg | 产品价格： | ￥6984.0 |
Product Introduction
Bioactivity
| 名称 | Aurora kinase inhibitor-2 |
| 描述 | Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). |
| 体外活性 | 在MCF-7细胞中，该化合物通过阻断增殖，展现出1.25 M的IC50值。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 22.5 mg/mL (56.19 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.99 mM), Sonication is recommended. |
| 关键字 | IUN70219 | IUN 70219 | Inhibitor | inhibit | AuroraKinase | Aurora-B | Aurora-A | Aurora kinase inhibitor-2 | Aurora kinase inhibitor2 | Aurora kinase inhibitor 2 | Aurora Kinase | Aurora A | ATP-competitive |
| 相关产品 | TCS7010 | Palmatine | MBM-55S | KW-2449 | Alisertib | MK-8745 | 6K465 | TAK-901 | SC-514 | CCT129202 | Palmatine chloride | SP600125 |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Kinase Inhibitor Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Epigenetics Compound Library | Multi-Target Compound Library | Membrane Protein-targeted Compound Library | Post-Translational Modification Compound Library |
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文献和实验The Ipl1/Aurora Kinase Family: Methods of Inhibition and Functional Analysis in Mammalian Cells
and the pharmaceutical industry. Indeed, two small molecule Aurora kinase inhibitors have recently been described. In this chapter, we describe several methods for investigating the function of the Aurora kinases, focusing on Aurora B. We describe the use of the small
MAP Kinase Regulation of the Mitotic Spindle Checkpoint
is guaranteed is through the activation of cell cycle checkpoints. The mitotic spindle checkpoint, which is regulated by Aurora B kinase, ensures proper kinetochore attachment to chromosomes leading to equal distribution of chromosomes to daughter cells
or phosphoproteome. In this protocol, we describe methodology to study the impact of kinase inhibitors on the proteome and phosphoproteome using mass spectrometry-based quantitative proteomics. More specifically, we focus on the effects of Aurora B kinase inhibitors
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