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- 文献和实验
- 技术资料
- CAS号:
303-98-0
- 规格:
50mg
Product Introduction
Bioactivity
| 名称 | Coenzyme Q10 |
| 描述 | Coenzyme Q10 (CoQ10) is a naturally occurring lipid-soluble quinone compound derived from Fusarium oxysporum. Coenzyme Q10 functions as an electron carrier in the mitochondrial respiratory chain, sustaining mitochondrial energy metabolism. Coenzyme Q10 is applicable in research on mitochondrial dysfunction, oxidative stress damage, cardiovascular diseases, and neurodegenerative disorders. |
| 体外活性 | 方法:分离的大鼠肝线粒体加入 Coenzyme Q10 (16, 32, 48, 64, 80 μg/mL),测定无机磷释放量,反映 ATP 酶活性。 结果:PCK 和 Coenzyme Q10 各浓度均能增加线粒体 ATP 酶活性。[1] 方法:小鼠原代腹腔巨噬细胞加入 Coenzyme Q10 (20 µM) 预处理 2 小时后,加 LPS (1 µg/ml) 刺激 6, 12, 18 小时,DCFH-DA 荧光探针法检测 ROS。 结果:Coenzyme Q10 处理显著抑制了 LPS 诱导的巨噬细胞内 ROS 的产生。[2] |
| 体内活性 | 方法:从小鼠心肌梗死术前 3 天开始灌胃给药 Coenzyme Q10 (600 mg/kg/d),每日一次,持续至术后 28 天。 结果:Coenzyme Q10 显著减少了心肌梗死后的心肌纤维化面积,减轻了梗死边缘区的心肌细胞肥大。[2] |
| 存储条件 | Store at low temperature,The compound is unstable in solution. Please use soon Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMF : 1 mg/mL (1.16 mM), Sonication and heating are recommended. DMSO : < 1 mg/mL (insoluble or slightly soluble), The compound is unstable in solution, please use soon. |
| 关键字 | Ubiquinone10 | Ubiquinone 10 | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | Ferroptosis | EndogenousMetabolite | Endogenous Metabolite | CoQ-10 | CoQ 10 | Coenzyme Q-10 | Coenzyme Q10 | Coenzyme Q 10 |
| 相关产品 | Guanidine hydrochloride | Glycerol | Aceglutamide | Malic acid | DL-Lysine | Sucrose | Guanidine thiocyanate | Hemin | Gluconate Calcium | Thymidine | D(+)-Raffinose pentahydrate | Ethyl linoleate |
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文献和实验/aptrix/upp00919.nsf/(FileDownload)?OpenAgent&docid=B9EC173AF3C88B18C1256EB400417CCF&file=Proc.PlusTechMan.pdf 亲和层析原理和方法(160页) http://www5.amershambiosciences.com/aptrix/upp00919.nsf/(FileDownload)?OpenAgent&docid=91D3DF5DE303E8B6C1256EB400417F34&file
身高组段(1) 频数(2) 累计频数*(3) 累计频率(%)(4) 概率单位(5) 162~ 1 1 0.9 2.63 164~ 4 5 4.5 3.30 166~ 9 14 12.7 3.86 168~ 13 27 24.5 4.31 170~ 19 46 41.8 4.79 172~ 27 73 66.4 5.42 174~ 16 89 80.9 5.87 176~ 8 97 88.2 6.19 178~ 8 105 95.5 6.70 180~ 3 108 98.2
2, passaging cells in SILEC expansion medium three more times. At this point, CoA species should be greater than 98% labeled. If cell growth or morphological characteristics are considerably affected, see TROUBLESHOOTING. NOTE: pause poInt Harvest
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