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- CAS号：
378-44-9
- 规格：
1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥470.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥117.0 |
| 规格： | 10mg | 产品价格： | ￥151.0 |
| 规格： | 25mg | 产品价格： | ￥226.0 |
| 规格： | 50mg | 产品价格： | ￥317.0 |
Product Introduction
Bioactivity
| 名称 | Betamethasone |
| 描述 | Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties. |
| 体外活性 | Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions. [1] |
| 体内活性 | Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. [1] Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. [2] Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. [3] Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. [4] Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10. [5] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.1 mM), Sonication is recommended. Ethanol : 10 mg/mL (25.48 mM), Sonication is recommended. DMSO : 73 mg/mL (186.01 mM), Sonication is recommended. |
| 关键字 | maturation | lung | Inhibitor | inhibit | immunosuppressive | GlucocorticoidReceptor | Glucocorticoid Receptor | glucocorticoid | gene | fetal | expression | Betamethasone | Apoptosis | anti-inflammatory |
| 相关产品 | Formamide | Urea | Sodium Molybdate | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen |
| 相关库 | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | ReFRAME Related Library | Bioactive Lipid Compound Library | FDA-Approved & Pharmacopeia Drug Library | Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Toxic Compound Library |
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文献和实验网络 三十二、实验动物器官与组织中胆碱酯酶活性 表12-67器官与组织中胆碱酯酶活性 [122] 动物种类 性别 体重（克） 动物数 测定单位 肝 肾 心 脑 肌 大鼠 ♂ 180～200 15 毫克/克・小时 198±6.4 44±2.6 〃 15 毫克分子/克・小时 378±
* 1,887 6,645 2.52. 8,893 2,726 −2.26 hsa-miR-126* 2,221 5,409 1.44* 5,578 6,111 0.10 4,749 6,410 0.35. 5,687 5,803 0.02*** hsa-miR-10b 1,695 3,564 1.10* 2,929 4,297 0.47** 378 411 0.09 371 382
0.44±0.03 0.7±0.04 197±0.3 小鼠 18 0.4±0.06 猫 3000～3500 14 0.9±0.1 102 ±17 豚鼠 300～320 24 378±9.6
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