- ￥231 - 3160
- TargetMol
- T4470
- 2026年07月07日
2 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- CAS号：
1472611-44-1
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥231.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥700.0 |
| 规格： | 5mg | 产品价格： | ￥506.0 |
| 规格： | 10mg | 产品价格： | ￥762.0 |
| 规格： | 25mg | 产品价格： | ￥1432.0 |
| 规格： | 50mg | 产品价格： | ￥2144.0 |
| 规格： | 100mg | 产品价格： | ￥3160.0 |
Product Introduction
Bioactivity
| 名称 | Pyridostatin TFA |
| 描述 | Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. |
| 细胞实验 | Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments. |
| 体外活性 | Pyridostatin通过激活DNA损伤检查点，降低MRC-5–SV40细胞和各种癌细胞系的增殖，并诱导细胞周期阻滞。同时，Pyridostatin通过与SRC中的G-四联体结构相互作用，减少MDA-MB-231细胞中依赖SRC的细胞移动性。此外，Pyridostatin还通过抑制G-四联体降低EBNA1的合成。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 52 mg/mL (55.4 mM), Sonication is recommended. |
| 关键字 | structure | SRC | RR-82 | RR82 | RR 82 | RNASynthesis | RNA Synthesis | Pyridostatin TFA | Pyridostatin | neurodegeneration | Inhibitor | inhibit | G-quadruplex | DSB | DNASynthesis | DNA Synthesis | DNA | damage | cycle | arrest |
| 相关产品 | Carbazole | Hexane-1,6-diol | Guanidine hydrochloride | Vidarabine | 1,4-Naphthoquinone | 5-Fluorouracil | Usnic Acid | Adenine hemisulfate | Erythromycin thiocyanate | Adenine | Docosanoic acid | Thymidine |
| 相关库 | Anti-Breast Cancer Compound Library | Bioactive Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Fluorochemical Library | Anti-Aging Compound Library | NO PAINS Compound Library | DNA Damage & Repair Compound Library |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
官网有文献
技术资料暂无技术资料 索取技术资料
文献支持
化合物 Pyridostatin TFA【1472611-44-1】
￥231 - 3160
