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- 2026年07月07日
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- CAS号：
1015474-32-4
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mg | 产品价格： | ￥202.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥471.0 |
| 规格： | 5mg | 产品价格： | ￥430.0 |
| 规格： | 10mg | 产品价格： | ￥662.0 |
| 规格： | 25mg | 产品价格： | ￥1320.0 |
| 规格： | 50mg | 产品价格： | ￥2072.0 |
| 规格： | 100mg | 产品价格： | ￥3304.0 |
| 规格： | 200mg | 产品价格： | ￥4704.0 |
Product Introduction
Bioactivity
| 名称 | Avadomide |
| 描述 | Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity. |
| 细胞实验 | Diffuse Large B-Cell Lymphoma are cultured in RPMI-1640 containing 10-20% fetal bovine serum, 1% Penicillin/Streptomycin and 1 mM sodium pyruvate. 2×104 cells are plated per well in media containing either DMSO or various concentrations of CC-122. Cells are cultured for 5 days at 37 degrees Celsius after which tritiated thymidine is added to the cell culture for the final 6 hours. Cells are subsequently harvested onto filter plates. After the plates have dried, scintillation fluid is added to the plates and read on a Top-count reader(Only for Reference) |
| 体外活性 | Avadomide是针对DLBCL的新型化合物，具有抗肿瘤和免疫调节活性。在DLBCL细胞系中，它通过结合CRBN并诱导Aiolos和Ikaros的降解或短发夹RNA介导的敲除来发挥作用，这与IFN（干扰素）刺激基因的增加转录相关，而这一过程是独立于IFN-α、-β和-γ的产生和/或分泌的，最终导致在活化的B细胞（ABC）和生发中心B细胞DLBCL细胞系中诱发凋亡。CRBN是Avadomide的分子靶点，Avadomide与CRBN的结合吸引了Aiolos/Ikaros到CRL4CRBN，并且E3连接酶的酶活性对于Aiolos和Ikaros的泛素化以及通过Avadomide引起的它们的蛋白酶体降解是必需的。Avadomide诱导IFN调节的蛋白质表达，并且它对IFN途径的影响是独立于自分泌型I和II IFN的分泌和信号传导的[1]。 |
| 体内活性 | Avadomide在ABC-和GCB-DLBCL细胞系建立的异种移植模型中减缓肿瘤生长，并在原代T细胞中刺激IL-2的产生。此外，在单臂Avadomide临床试验中，接触Avadomide使每位患者的Aiolos和Ikaros表达水平下降了25%至50%，证明这两种蛋白作为Avadomide药效学标志物的有效性[1]。 |
| 存储条件 | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 1 mg/mL (3.49 mM), Sonication is recommended. DMSO : 250 mg/mL (873.24 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (34.93 mM), Solution. 10% DMSO+90% Saline : < 10 mg/mL (34.93 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| 关键字 | Ubiquitin ligase | Ubiquitin conjugating enzyme | Ubiquitin activating enzyme | orally | lymphoma | ligase | LigandforE3Ligase | Ligand for E3 Ligase | large | Inhibitor | inhibit | immunomodulatory | E3Enzyme | E3 ligating enzyme | E3 Ligase | E3 Enzyme | E2Enzyme | E2 Enzyme | E2 conjugating enzyme | E1Enzyme | E1/E2/E3 Enzyme | E1 Enzyme | E1 activating enzyme | DLBCL | diffuse | cereblon | CC-122 | CC122 | B-cell | Avadomide | Apoptosis | antitumor |
| 相关产品 | Formamide | Urea | D-Psicose | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Stavudine | Tamoxifen | Ethyl linoleate |
| 相关库 | Anti-Cancer Active Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | Apoptosis Compound Library | Anti-Aging Compound Library | HIF-1 Signaling Pathway Compound Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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化合物Avadomide【1015474-32-4】
￥202 - 4704
