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- 2026年07月07日
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- 技术资料
- CAS号：
1799725-26-0
- 规格：
1mLx10mM(inDMSO)/2mg/5mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥1096.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥592.0 |
| 规格： | 5mg | 产品价格： | ￥984.0 |
Product Introduction
Bioactivity
| 名称 | GSK180 |
| 描述 | GSK180 is a selective, competitive, and highly potent inhibitor of kynurenine-3-monooxygenase (KMO), a critical enzyme in the tryptophan metabolic pathway, with an IC50 value of approximately 6 nM, displaying minimal off-target activity against other tryptophan pathway enzymes, rapidly altering kynurenine metabolite profiles, GSK180 serves as a powerful research tool for probing the biological and therapeutic implications of KMO inhibition in metabolic, neurological, and inflammatory disease models. |
| 体外活性 | GSK180 inhibits endogenous KMO activity in primary human hepatocytes (IC50=2.6 μM) and it also inhibits rat KMO slightly less potently than the human enzyme (IC50=7 μM). |
| 体内活性 | GSK180 is fit for i.v. management [1]. |
| 存储条件 | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 200 mg/mL (724.45 mM), Sonication is recommended. |
| 关键字 | KMO |
| 相关产品 | SU 10603 | pCPA methyl ester hydrochloride | Cuprizone | Casein | Telotristat Etiprate | Mildronate | 4-Chloro-L-phenylalanine | p-Fluoro-L-phenylalanine | Fenclonine | Fusaric acid | Ketoconazole | Tetrahydropapaverine hydrochloride |
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化合物 GSK180【1799725-26-0】
￥592 - 1096
