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- 2026年07月07日
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- CAS号：
141117-12-6
- 规格：
1mLx10mM(inDMSO)/2mg/5mg/25mg/50mg/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥3176.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥1456.0 |
| 规格： | 5mg | 产品价格： | ￥2656.0 |
| 规格： | 25mg | 产品价格： | ￥9280.0 |
| 规格： | 50mg | 产品价格： | ￥12080.0 |
| 规格： | 100mg | 产品价格： | ￥17200.0 |
Product Introduction
Bioactivity
| 名称 | Celgosivir hydrochloride |
| 描述 | Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM). |
| 体外活性 | Celgosivir is more effective (IC50: 20 μM) than the parent molecule (IC50: 254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 (IC50: 2.0 μM) [1]. BVDV is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively [2]. Celgosivir inhibits DENV2 replication with an EC50 of 0.2 μM. The EC50 values against DENV1, 3, and 4 are less than 0.7 μM [3]. |
| 体内活性 | During primary infection with a mouse-adapted DENV strain S221, mice show increased viremia on day 3, yet 80% survived day 10 with a virus completely cleared by day 8 [3]. Celgosivir (50 mg/kg, BID for 5 days) fully protects AG129 mice from lethal infection with a mouse-adapted dengue virus and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25, or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice show that it rapidly metabolizes to castanospermine [4]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 100 mg/mL (338.11 mM), Sonication is recommended. DMSO : 100 mg/mL (338.11 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (11.16 mM), Sonication is recommended. |
| 关键字 | α-glucosidase I | MX-3253 Hydrochloride | MX3253 Hydrochloride | MX 3253 Hydrochloride | MDL-28574 Hydrochloride | MDL28574 Hydrochloride | MDL 28574 Hydrochloride | MBI-3253 Hydrochloride | MBI3253 Hydrochloride | MBI 3253 Hydrochloride | Celgosivir hydrochloride |
| 相关产品 | Penicillin G potassium | Valproic Acid | (-)-Epigallocatechin Gallate | Emtricitabine | (E)-3-(p-Tolyl)acrylaldehyde | Dextran sulfate sodium salt (MW 5000) | Lamivudine | 5-Fluorouracil | Decanedioic acid | Stavudine | Dimethyl fumarate | Sofosbuvir |
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文献和实验0.1 0.000266 Thiamine hydrochloride 337 1 0.00297 Vitamin B12 1355 1.36 0.00100 3、Inorganic Salts Calcium Chloride (CaCl2) (anhyd.) 111 200 1.80 Magnesium Sulfate (MgSO4) (anhyd.) 120 97.67 0.814 Potassium Chloride (KCl) 75
ml，0.01mol/l pH7.4 PBS 90ml）。 （3）4%多聚甲醛磷酸缓冲液pH7.4（多聚甲醛40g,0.1mol/L PBS液pH7.4500ml，两者混 合加热至60℃，搅拌并滴加1n NaOH至清晰为止，冷却后加PBS液至总量1000ml）。 （4）戊二醛-甲醛液（戊二醛1ml，浓甲醛10ml，蒸馏水加至100ml）。 戊二醛是二醛基化合物，交联结合力比甲醛大，Bullock认为交联过强，可出现组织改变和空间遮蔽现象，影响组织的抗原性。但McDonald等认为，该试剂用于PAP
Glutathione 还加入一定的L-Arginine-Hydrochloride 12-24h 4) 复性完毕在低浓度的缓冲液中连续缓慢透析12-24h 5) 复性率的测定 据变性蛋白和非变性蛋白的光学性质不同测定（望有经验的战友能更详细地讲解） 6）TritionX100、SDS这一类去垢剂最后不易去除，在制药行业中一般不允许采用。好像SDS最后残留量不能大于0.5%吧，忘了。 我用Triton洗涤有些包涵体效果不是很好。包涵体洗涤是纯化极为重要的一步，改变培养条件，再洗涤包涵体，有时可以在上柱前已经
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