- ￥229 - 4256
- TargetMol
- T23800
- 2026年07月07日
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- CAS号：
1422252-46-7
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥229.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥553.0 |
| 规格： | 5mg | 产品价格： | ￥504.0 |
| 规格： | 10mg | 产品价格： | ￥856.0 |
| 规格： | 25mg | 产品价格： | ￥1720.0 |
| 规格： | 50mg | 产品价格： | ￥2864.0 |
| 规格： | 100mg | 产品价格： | ￥4256.0 |
Product Introduction
Bioactivity
| 名称 | BI-9627 hydrochloride |
| 描述 | BI-9627 hydrochloride is a highly potent Na⁺/H⁺ exchanger 1 (NHE1) inhibitor. In intracellular pH recovery assays and human platelet swelling assays, its IC₅₀ values are 6 nM and 31 nM, respectively. It shows more than 30-fold selectivity over NHE2 and has no significant inhibitory effect on NHE3. BI-9627 hydrochloride can reduce the autophagy level of HTR-8/SVneo cells, significantly decrease the intracellular pH of human sperm, partially reverse the effect of DMA, and prolong the Ca²⁺ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride has a low risk of drug-drug interactions, exhibits favorable pharmacokinetic properties in rats and dogs, and demonstrates potent activity in an ex vivo heart model of ischemia-reperfusion injury. |
| 存储条件 | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 80 mg/mL (203.67 mM), Sonication is recommended. H2O : 3.33 mg/mL (8.48 mM), Sonication is recommended. |
| 关键字 | BI-9627 Hydrochloride | BI9627 hydrochloride | BI9627 Hydrochloride | BI 9627 hydrochloride | BI 9627 Hydrochloride |
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