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- 文献和实验
- 技术资料
- CAS号：
1254032-66-0
- 规格：
25mg/50mg/100mg
| 规格： | 25mg | 产品价格： | ￥12000.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥15840.0 |
| 规格： | 100mg | 产品价格： | ￥20400.0 |
Product Introduction
Bioactivity
| 名称 | Netarsudil free base |
| 描述 | Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 关键字 | Netarsudil free base | Netarsudil | ABI274 | ABI 274 |
| 相关产品 | Y-27632 dihydrochloride | ITX3 | Fasudil hydrochloride | ROCK-IN-5 | Fostamatinib | Fasudil | Tofacitinib | Y-27632 | Tetrabenazine | RKI-1447 | Thiazovivin | GSK180736A |
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文献和实验Secondary structure of prion mRNA
of single-stranded RNA is presented. For each RNA of a set of homologous RNAs, optimal and suboptimal secondary structures are calculated and stored in a base-pair probability matrix. A multiple sequence alignment is performed for the set of RNAs
细菌RNA的提取--ISOLATION OF RNA FROM BACTEROIDS
at 8000 rpm. To the supernatant add 0.7 vol isopropanol, chill, spin again, and resuspend pellet in 5 ml.5X Running buffer for RNA (formaldehyde) gels: (For 500 ml) 2 ml 0.5 M EDTA, 6.8 g Na acetate, 12.8 g MOPS (free acid), 9.0 g MOPS (base).Induce cells
RNA Secondary Structure Analysis Using RNAstructure
. 2004. Using an RNA secondary structure partition function to determine confidence in base pairs predicted by free energy minimization. RNA 10:1178‐1190. Mathews, D.H. 2005
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