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- 2026年07月07日
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AJE 润色服务限时 8 折起，权威机构信任 15+ 年Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
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- 技术资料
- CAS号：
1195941-38-8
- 规格：
1mg/1mLx10mM(inDMSO)/2mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥888.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥2624.0 |
| 规格： | 2mg | 产品价格： | ￥1568.0 |
| 规格： | 5mg | 产品价格： | ￥2544.0 |
| 规格： | 10mg | 产品价格： | ￥3728.0 |
| 规格： | 25mg | 产品价格： | ￥5904.0 |
| 规格： | 50mg | 产品价格： | ￥7960.0 |
| 规格： | 100mg | 产品价格： | ￥10640.0 |
Product Introduction
Bioactivity
| 名称 | Edg-2 receptor inhibitor 1 |
| 描述 | Edg-2 receptor inhibitor 1 (SAR-100842) is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM). |
| 体外活性 | Edg-2 receptor inhibitor 1 是一种针对内皮分化基因受体2（Edg-2, EDG2）的抑制剂，该受体由溶血磷脂酸（LPA）激活，并且也被称为LPA1受体。该化合物可用于治疗如动脉粥样硬化、心肌梗塞和心力衰竭等疾病[1]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : < 4.17 mg/mL (9.36 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.17 mg/mL (9.36 mM), Solution. DMSO : 41.67 mg/mL (93.53 mM), Sonication is recommended. |
| 关键字 | SAR100842 | SAR 100842 | LPAReceptor | LPA Receptor | Edg-2 receptor inhibitor 1 | Edg2 receptor inhibitor 1 | EDG2 | Edg 2 receptor inhibitor 1 |
| 相关产品 | Tetradecyl Phosphonate | Radioprotectin-1 | H2L5186303 | TAK-615 | GRI977143 | ACT-1016-0707 | LPA1 receptor antagonist 1 | H2L 5765834 | Ki16198 | DBIBB | Ki16425 | UCM-05194 |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library | GPCR Compound Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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文献和实验Overview of Receptor Allosterism
. Bruns, R.F. and Fergus, J.H. 1990. Allosteric enhancement of adenosine A1 receptor binding and function by 2‐amino‐3‐benzoylthiophenes. Mol. Pharmacol. 38:939‐949.
【求助】急急求助答案——关于SB203580抑制P38MAPK的自身磷酸化
203580 inhibitor blocks the activity of p38, i.e. its ability to phosphorylate its substrates. It does not block the phosphorylation of p38 itself. (see kumar et al, 1999, Biochem Biophys Res Commun 268:825-831). 意思是说它不能抑制P38的磷酸化，而是抑制P38对其底物的活化，原始文献我也没怎么看明白，要求
Using AutoDock for Ligand‐Receptor Docking
crystal structure of Indinavir bound to HIV?1 protease taken from the Protein Data Bank (UNIT 1.9 ) and shows how to prepare the ligand and receptor for AutoGrid, which computes grid maps needed by AutoDock. Indinavir is prepared for AutoDock, adding
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