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- 文献和实验
- 技术资料
- CAS号：
222638-67-7
- 规格：
1mg/1mLx10mM(inDMSO)/2mg/5mg/10mg/25mg/50mg
| 规格： | 1mg | 产品价格： | ￥239.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥693.0 |
| 规格： | 2mg | 产品价格： | ￥333.0 |
| 规格： | 5mg | 产品价格： | ￥618.0 |
| 规格： | 10mg | 产品价格： | ￥1096.0 |
| 规格： | 25mg | 产品价格： | ￥2128.0 |
| 规格： | 50mg | 产品价格： | ￥3192.0 |
Product Introduction
Bioactivity
| 名称 | BEC hydrochloride |
| 描述 | BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II, and is 0.4-0.6 μM for rat Arginase I. |
| 激酶实验 | PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ enzyme assays: The inhibition of PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ human recombinant PI3K isoforms is evaluated using a Kinase-Glo Plus Assay Kit. 12 point half-log concentration-response curves with a top concentration of 100 μM are constructed by dispensing DMSO solubilised compounds into white 384-well medium-binding microplates using an Echo 555. 3 μL of the appropriate PI3K? in Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 mM DTT, and 10 mM MgCl2) is added. The plate is covered and allowed to pre-incubate with compound for 20 minutes prior to addition of 3 μL of substrate solution containing PIP2 and ATP. The enzyme reaction is stopped after 80 minutes by the addition of Kinase Glo detection solution. Plates are covered and incubated for 30 minutes at room temperature before the luminescence signal is read using a PHERAstar plate reader. The final concentrations of DMSO, ATP and PIP2 in the assay are 2%, 8 μM, and 80 μM respectively. The final concentrations of PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ are respectively 20 nM, 20 nM, 45 nM and 30 nM. For PI3Kα, PI3Kβ and PI3Kδ the concentration of active enzyme is determined as outlined in the enzyme assay tight binding limit determination section. For PI3Kγ the concentration of enzyme is determined by Bradford assay. IC50 values are calculated using Genedata Screener. |
| 体外活性 | BEC causes significant enhancement of NO-dependent smooth muscle relaxation. [2] In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. [3] BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK. [5] |
| 体内活性 | In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. [4] In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure. [5] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 31.25 mg/mL (136.17 mM), Sonication is recommended. Ethanol : 42 mg/mL (183.01 mM), Sonication is recommended. 10% DMSO+90% Saline : 3.13 mg/mL (13.64 mM), Suspension. H2O : 41 mg/mL (178.66 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.71 mM), Sonication is recommended. |
| 关键字 | rat Arginase I | NF-κB | metaplasia | Inhibitor | inhibit | inflammation | hyperresponsiveness | CCL20 | BEC Hydrochloride | BEC | Arginase-II | Arginase-2 | Arginase |
| 相关产品 | Urea | Numidargistat dihydrochloride | Guanidine hydrochloride | Arginase inhibitor 1 | L-Ornithine | L-Valine | DL-Norvaline | 2-Aminoimidazole | L-Norvaline | Piceatannol 3'-O-glucoside | Nω-Hydroxy-nor-L-Arginine Dihydrochloride | Nor-NOHA monoacetate |
| 相关库 | Inhibitor Library | Immuno-Oncology Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | NO PAINS Compound Library | Multi-Target Compound Library | Immunology/Inflammation Compound Library | Covalent Inhibitor Library |
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量激增。但我们或许忽略了一个问题：这些物质最终都去了哪里？这些化合物一定安全吗？ 目前，在环境相关浓度下，抗菌化学品对水生生物的发育毒性仍缺乏系统比较。三氯生（TCS）和三氯卡班（TCC）因安全隐患已被部分禁用，其替代品如苯扎氯铵（BAC）、苯乙氯铵（BEC）、氯二甲&酚（CX）被广泛使用，但它们的生态毒性是否真的低于被禁物质，尚属未知。 关键发现 本研究首次在环境相关浓度（0.4 µg/L 起）下，系统比较了五种常见抗菌剂对斑马鱼胚胎的发育毒性，发现替代品BAC的毒性甚至超过被禁的TCS
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率的大小是和用药的剂量或辐射累积效应呈正相关，这一点和染色体畸变的情况是一样的。所以许多人认为可用简易的间期微核计数来代替繁杂的中期畸变染色体计数。由于大量新的化合物的合成，原子能的应用，各种各样的工业废物的排出，使人们需要有一套高度灵敏，技术简单的测试系统来监视环境的变化。只有真核类的测试系统更能直接推测诱变物质对人类或其它高等生物的遗传危害。在这方面，微核测试是一种比较理想的方法。目前国内外不少部门已把“微核测试用于辐射损伤、辐射防护、化学诱变剂、新药试验、染色体遗传疾病及癌症前期诊断等各方
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化合物 BEC HCl【222638-67-7】
￥239 - 3192
