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- 2026年07月07日
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- CAS号：
131707-23-8
- 规格：
1mLx10mM(inDMSO)/2mg/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥172.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥110.0 |
| 规格： | 5mg | 产品价格： | ￥153.0 |
| 规格： | 10mg | 产品价格： | ￥230.0 |
| 规格： | 25mg | 产品价格： | ￥390.0 |
| 规格： | 50mg | 产品价格： | ￥589.0 |
| 规格： | 100mg | 产品价格： | ￥864.0 |
| 规格： | 500mg | 产品价格： | ￥2216.0 |
Product Introduction
Bioactivity
| 名称 | Umifenovir hydrochloride |
| 描述 | Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane. |
| 体外活性 | Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. [1] Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). [2] Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. [3] Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. [4] Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively. [5] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 21 mg/mL (40.87 mM), Sonication is recommended. DMSO : 250 mg/mL (486.49 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (19.46 mM), Suspension. 10% DMSO+90% Saline : < 10 mg/mL (19.46 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| 关键字 | virus | Umifenovir hydrochloride | Umifenovir | SARS-CoV | SARSCoV | SARS coronavirus | oral | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | Influenza A virus | inflammatory | fusion | enveloped | Arbidol Hydrochloride |
| 相关产品 | α-Cyclodextrin | Baicalein | Chloroquine phosphate | Salcomine | β-Cyclodextrin | Hydroxychloroquine | Nitazoxanide | Curcumin | Dihydromyricetin | Acetylcysteine | Benzimidazole | Rifampicin |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Aging Compound Library | Anti-COVID-19 Compound Library | Anti-Viral Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Target-Focused Phenotypic Screening Library | NMPA-Approved Drug Library |
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盐酸阿比多尔【131707-23-8】
￥110 - 2216
