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- CAS号：
2133364-01-7
- 规格：
25mg/50mg/100mg
| 规格： | 25mg | 产品价格： | ￥11920.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥15536.0 |
| 规格： | 100mg | 产品价格： | ￥19700.0 |
Product Introduction
Bioactivity
| 名称 | Vildagliptin dihydrate |
| 描述 | Vildagliptin dihydrate (LAF237 dihydrate) is a powerful and stable dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating selectivity with an IC50 of 3.5 nM in human Caco-2 cells. This compound exhibits exceptional oral bioavailability and significant antihyperglycemic activity [1]. |
| 体外活性 | Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation [2]. |
| 体内活性 | Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice [2]. Vildagliptin (10 μmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats [1]. Animal Model: Male db/db mice (BKS) and wildtype mice [2] Dosage: 35 mg/kg Administration: Oral gavage; once daily; for 6 weeks Result: Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44). Animal Model: Obese male Zucker rats [1] Dosage: 10 μmol/kg (Pharmacokinetic Analysis) Administration: Orally Result: Significantly decreased glucose excursions and stimulate insulin secretion. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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化合物 Vildagliptin dihydrate【2133364-01-7】
￥11920 - 19700
