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- TargetMol
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- 2026年07月07日
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- CAS号：
1314241-44-5
- 规格：
1mLx10mM(inDMSO)/2mg/5mg/10mg/25mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥177.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥108.0 |
| 规格： | 5mg | 产品价格： | ￥156.0 |
| 规格： | 10mg | 产品价格： | ￥252.0 |
| 规格： | 25mg | 产品价格： | ￥383.0 |
Product Introduction
Bioactivity
| 名称 | UNC 669 |
| 描述 | UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3. |
| 激酶实验 | In vitro Enzyme Assays.: All in vitro enzyme assays are done at Upstate Biotechnology with the exception of InsR and IGF-1R. To determine the IC50 of TAE684 against InsR and IGF-1R a homogeneous time-resolved fluorescence assay is performed. ATP (10 mM) and 20 mg/ml biotinylated PolyEY (Glu, Tyr 4:1) are combined with 50 nL of serial dilutions of TAE684 (10-500 nM) and 4 ng of InsR enzyme in the presence of the kinase reaction buffer (20 mM Tris譎Cl, pH 7.5/10 mM MgCl2/3 mM MnCl2/1 mM DTT/10 mM NaVO4/0.1 mg/ml of BSA). Assays are incubated for 1 hour at ambient temperature. Reactions are terminated by adding 10 mL of the detection solution containing 50 mM EDTA, 500 mM KF, 0.5 mg/ml of BSA, 5 mg/mL Eu3+ cryptate-labeled anti-phosphotyrosine antibody Mab PT66-K, and 5 mg/mL Streptavidin-XLent. The reaction is incubated for half an hour, and fluorescence signals are read on Analyst GT. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 9 mg/mL (26.61 mM), Sonication is recommended. Ethanol : 63 mg/mL (186.26 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.96 mM), Sonication is recommended. |
| 关键字 | UNC 669 | transcriptional | repression | repeats | MBT | L3MBTL4 | L3MBTL3 | L3MBTL1 | Inhibitor | inhibit | EpigeneticReaderDomain | Epigenetic Reader Domain |
| 相关产品 | Bisdemethoxycurcumin | dBET6 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | CeMMEC1 | JQ-1 (carboxylic acid) | SNDX-5613 | (+)-JQ-1 | Curcumin | Naphthol AS-E | J-147 | ABBV-744 | 5-Ph-IAA |
| 相关库 | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Chromatin Modification Compound Library | Histone Modification Compound Library | Anti-Aging Compound Library | NO PAINS Compound Library | Epigenetics Compound Library | Multi-Target Compound Library | Reprogramming Compound Library |
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文献和实验C18 H44 O，麦角甾 -5， 7， 22-三烯 -3β -醇， 24s-甲基胆甾 -5， 7， 22-三烯 -3β -醇。含于酵母、麦角、香蕈等中的甾醇。是重要的维生素 D原之一，经紫外线作用成为麦角钙化醇（ ergocalciferol，维生素 D2 ）。易溶于热醇、醚、氯仿中，与毛地黄皂苷形成分子化合物。
Crystallization of Kinesin Family Motor Proteins
)(Gulick et al.,1998; Yun et al.,2001)and three KAR3 mutants (Yun et al.,2001),and KCBP (Vinogradova et al.,2004); the Kinesin-3 (formerly Unc104/KIF1)motor,KIF1A bound to different nucleotides (KIF1A-ADP,KIF1A-AMPPCP,KIF1A-ADP-Vi,KIF1A-AlFx)(Kikkawa et al
"cosuppression", since the expression of both the introduced gene and the homologous endogenous gene was suppressed (1-5).First thought to be a quirk of petunias, cosuppression has since been found to occur in many species of plants. It has also been observed
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