- ￥105 - 322
- TargetMol
- T41358
- 2026年07月07日
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- CAS号：
932-30-9
- 规格：
1mLx10mM(inDMSO)/1g/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥109.0 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ￥322.0 |
| 规格： | 100mg | 产品价格： | ￥105.0 |
| 规格： | 500mg | 产品价格： | ￥207.0 |
Product Introduction
Bioactivity
| 名称 | 2-Hydroxybenzylamine |
| 描述 | 2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial arrhythmias following atrial fibrillation ablation by decreasing IsoLG adducts with native biomolecules. |
| 体内活性 | 与治疗组（接受4-Hydroxybenzylamine或载体处理）相比，Ldlr-/-高胆固醇血症小鼠使用2-Hydroxybenzylamine后在不改变血浆胆固醇水平的情况下，面对主动脉粥样硬化程度降低了60%。采用2-Hydroxybenzylamine处理的Ldlr-/-小鼠显示出MDA-LDL与MDA-HDL水平降低，且其HDL在降低巨噬细胞胆固醇方面的能力增强。值得注意的是，相较于4-Hydroxybenzylamine，2-Hydroxybenzylamine能显著减少粥样硬化主动脉中的MDA-和IsoLG-lysyl含量。此外，2-Hydroxybenzylamine还能减轻炎症、减少斑块中的凋亡细胞、促进死细胞的有效清除，并且促进稳定斑块的特征表现。使用2-Hydroxybenzylamine作为二羰基清除剂，在小鼠家族性高胆固醇血症模型中展现出多重抗动脉硬化效应。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (16.24 mM), Sonication is recommended. DMSO : 45 mg/mL (365.41 mM), Sonication is recommended. |
| 关键字 | scavenger | Reactive Oxygen Species | radical | oxidative stress | o-Hydroxybenzylamine | IsoLGs | Inhibitor | inhibit | inflammation | FH model | atrial fibrillation | atherosclerosis | arrhythmias | antioxidant | 2-Hydroxybenzylamine | 2Hydroxybenzylamine | 2-HOBA | 2 Hydroxybenzylamine |
| 相关产品 | Allopurinol | L-Cystine | Kaolin | Magnesium acetate tetrahydrate | Dimethyl phthalate | Inosine | Cysteamine hydrochloride | Imeglimin hydrochloride | Ethoxyquin | L-Ascorbic acid sodium salt | Dimethyl itaconate | Ethyl linoleate |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | Selected Plant-Sourced Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Clinical Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | NF-κB Signaling Compound Library | RO5 Drug-like Natural Product Library |
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文献和实验thyroid carcinoma, paratesticular leiomyosarcoma (30%), pleomorphic hyalinizing angiectatic tumor, pseudoangiomatous stromal hyperplasia of breast, schwannomas (usually), sclerosing liposarcoma (spindle and atypical cells), solitary fibrous tumors
在溶剂中一周，就可以得到透明的脑组织，但是组织膨胀率高达 10%-30%。尿素溶液处理固定的脑组织，通过水合作用使组织透明，但相应的组织略膨胀，后续用 ScaleA2 溶液继续处理，ScaleA2 溶液包含 4M 尿素，10%（wt / vol）甘油和 0.1%（wt / vol）Triton X-100 组成。甘油可以防止过多的水合作用并使组织扩张最小化。在 ScaleA2 溶液中孵育完整的固定小鼠大脑，孵育时间 2 周以上可充分清除脑组织。在有图案的背景下或通过 532 nm 激光的穿透，透明
Purification of GST Fused Proteins
mg/ml DNasel (Boehringer #1284 932), swirl (final concentration 100ug/ml) Incubate ice 30 min. Start step 8. immediately. Preswell glutathione agarose beadsby adding 75mg beads to 10ml tube (#G-4510, 12 spacer atoms Sigma) Add PBS/10
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