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- TargetMol
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- 2026年07月07日
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- CAS号：
943820-93-7
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥912.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥412.0 |
| 规格： | 5mg | 产品价格： | ￥936.0 |
| 规格： | 10mg | 产品价格： | ￥1592.0 |
| 规格： | 25mg | 产品价格： | ￥2624.0 |
| 规格： | 50mg | 产品价格： | ￥3688.0 |
| 规格： | 100mg | 产品价格： | ￥4736.0 |
| 规格： | 500mg | 产品价格： | ￥9440.0 |
Product Introduction
Bioactivity
| 名称 | Wnt/β-catenin agonist 2 |
| 描述 | Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer invasion and metastasis. |
| 体外活性 | Wnt/β-catenin agonist 2 acts as a stimulator of β-Catenin in the SW480 cell line, enhancing its activity. Moreover, it has been observed that Wnt/β-catenin agonist 2 exerts an influence on the differentiation of ST2 cells, promoting their transformation into osteoblasts [1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : < 10 mg/mL (36.73 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. DMSO : 150 mg/mL (550.94 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (36.73 mM), Solution. |
| 关键字 | βcatenin | Wnt/β-catenin agonist 2 | Wnt/βcatenin agonist 2 | Wnt/β-catenin | Wnt/β catenin agonist 2 | Wnt/beta-catenin agonist 2 | Wnt/betacatenin | Wnt/b-catenin agonist 2 | Wnt/b-catenin | Wnt | GSK-3 | GSK3 | beta-catenin | betacatenin | bcatenin |
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文献和实验miaoduan 本人刚刚开始做实验，有关wnt通路的检测，想请教激活wnt通路的方法，看资料主要有三种： 1，加wnt蛋白 2，LiCl抑制gsk3β 3，转染wnt质粒或者点突变的β-catenin质粒 不知哪种方法可行，具体如何操作呢 非常感谢！！！ edwardellen 加wnt3a，看过一篇CANCER CELL是这样激活的 liubodoctor
a look from the following website just by clicking "Tyrosine Phosphorylation and Dimerization" http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-43F85YV-2&_user=1111158&_coverDate=06%2F29%2F2001&_rdoc=1&_fmt=full&_orig=search
Nature（IF=48.5）具有代谢功能的人成体肝细胞类器官的构建！
本文献研究首次建立可长期扩增且保留完整代谢功能的人成体肝细胞类器官（HHO），通过Wnt+STAT3双通路激活（关键因子为抑瘤素M，OSM）解决了体外肝细胞“扩增就丢失功能、保功能就无法扩增”的trade-off难题。OSM既能强力驱动增殖，又能阻止胆管化生，维持肝细胞身份。该类器官可在小鼠肝脏内定植重建、形成代谢分区，并完整复现胆汁酸合成、脂质代谢、药物代谢、糖异生、尿素循环等全部核心肝功能；同时支持高效基因编辑，可构建糖原贮积病、尿素循环障碍等代谢肝病模型。该体系为肝病机制研究、药物
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