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- 2026年07月07日
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- 技术资料
- CAS号：
733767-34-5
- 规格：
2mg
Product Introduction
Bioactivity
| 名称 | NSC 23766 |
| 描述 | NSC 23766 is a Rac1 GTPase inhibitor that inhibits Rac1 activation by targeting guanine nucleotide exchange factors (GEFs), while it has no inhibitory effect on the closely related targets Cdc42 and RhoA, affecting the cell cycle and inhibiting cell proliferation in a dose-dependent manner. It also regulates endothelial NO synthase expression and endothelial function, and inhibits platelet aggregation and γ-secretase activity.NSC23766 competitively inhibits M2 muscarinic acetylcholine receptor (M2 mAChR)-induced Rac1 activation in neonatal rat cardiomyocytes. |
| 体外活性 | NSC 23766 (200 μM) 处理卵母细胞，增加了卵母细胞形态异常纺锤体的百分比，并且p-MAPK 蛋白表达显著降低。[2] |
| 体内活性 | NSC 23766（2.5 mg/kg/天，腹腔注射）处理NOD 小鼠，显著减缓了 NOD 小鼠自发性糖尿病的发病，且对小鼠的生长（体重）无显著影响。[1] |
| 存储条件 | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (7.83 mM), Sonication is recommended. DMSO : 80 mg/mL (189.76 mM), Sonication is recommended. |
| 关键字 | NSC-23766 | NSC 23766 |
| 相关产品 | Mitotane | Hexamethonium Bromide | RMC-9805 | Urethane | Levamisole hydrochloride | Arecoline | Daraxonrasib | Sotorasib | Adenine | N,N-Dicyclohexylcarbodiimide | Adiphenine hydrochloride | Ribavirin |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Neurotransmitter Receptor Compound Library | Neuronal Signaling Compound Library | MAPK Inhibitor Library | GPCR Compound Library | Multi-Target Compound Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library |
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文献和实验，那如果是的话hsa-mir-34a在mirbase的书写顺序是不是从3'-5'? 如果有某个转录因子结合在hsa-mir-34a的上游10bp区域，是不是就是指的AAGAGGGAAG？ 我都有些晕了 吴佰霖 是不是两者范围不一样？ 吴佰霖 >hsa-mir-34a MI0000268 麦丽素 同问，前体miRNA的侧翼序列到底是指的哪个范围？是编码
Neurosphere and Neural Colony-Forming Cell Assays
), neural stem cells (NSC) are often isolated and studied using a culture system referred to as the neurosphere assay. Since its introduction in 1992, the neurosphere system has been used to isolate, expand, and identify the presence of an NSC population
元元上回用 targetscan 和 starbase 告诉大家查找 miRNA 结合位点，如何用数据库查找 miRNA 结合位点（今天学的是寻找基因的 3’UTR 和 miRNA 的碱基序列，最终预测 miRNA 与目标 mRNA 在 3’UTR 的结合位点）例如咱们在 starbase 看到如下结果：划红线的结果是 miR34A-5P 与 BCL2 存在结合位点，有三个数据库预测到这种关系。现在咱们用 RNA22Sites 这个网站也来寻找 miRNA 结合位点。进入这个网站：https
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