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- 技术资料
- CAS号：
142439-94-9
- 规格：
1mg
Product Introduction
Bioactivity
| 名称 | Rp-cAMPS sodium |
| 描述 | Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases. |
| 体外活性 | 方法：为了测量 Rp-cAMPS sodium 对纯化的 II 型 cAMP 依赖性蛋白激酶的抑制作用。通过添加不同浓度的 Rp-cAMPS sodium ，观察其对 cAMP 诱导的磷酸转移酶活性的影响。 结果：Rp-cAMPS sodium 与 cAMP 结合，但不引起酶的解离，从而抑制了磷酸转移酶的活性[2]。 |
| 体内活性 | 方法：为了探讨 Rp-cAMPS sodium 对关节炎大鼠模型中突触传递的影响，特别是其对 PB-CeLC 和 BLA-CelC 突触的调节作用，通过刺激 PB-CeLC 和 BLA-CelC 突触，记录诱发的 EPSC，并比较处理前后的变化。 结果：Rp-cAMPS sodium (10 μM，15 分钟)的处理显著减少了 PB-CeLC 和 BLA-CelC 突触诱发的单突触 EPSC[2]。 |
| 存储条件 | Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 80 mg/mL (217.84 mM), Sonication is recommended. |
| 关键字 | RpcAMPS sodium salt | Rp-cAMPS sodium | Rp cAMPS sodium salt | pka | cAMP |
| 相关产品 | Rhamnose monohydrate | Bucladesine sodium | JAK1/2/3 Inhibitor 1 | Taurodeoxycholate sodium salt | Fasudil hydrochloride | Acefylline | Ellagic acid | Undecane | Bithionol | D-Mannitol | Tetramisole hydrochloride | Isovaleric acid |
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文献和实验Reducing Sample Complexity by RP-HPLC: Beyond the Tip of the Protein Expression Iceberg
-phase high-performance liquid chromatography (RP-HPLC), separating proteins according to their hydrophobicity. This effectively introduces a third separation dimension, increasing the spatial resolution of the experiment
Imaging cAMP Dynamics in the Drosophila Brain with the Genetically Encoded Sensor Epac1-Camps
, we describe a detailed protocol for the monitoring of neuronal cAMP dynamics during bath application of neurotransmitters and neuromodulators using the genetically encoded cAMP sensor Epac1-camps and scanning laser confocal microscopy.
in a multiple reaction. The SNuPE product, without further purification, is separated by ion-pair reverse-phase (IP RP) high-performance liquid chromatography (using an alkylated nonporous polysterene-divinylbenzene cartridge) that allows an easy, semiautomated
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