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- 文献和实验
- 技术资料
- CAS号：
491-67-8
- 规格：
1mLx10mM(inDMSO)/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥324.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥218.0 |
| 规格： | 100mg | 产品价格： | ￥334.0 |
| 规格： | 500mg | 产品价格： | ￥797.0 |
Product Introduction
Bioactivity
| 名称 | Baicalein |
| 描述 | Baicalein (5,6,7-Trihydroxyflavone) belongs to the flavonoid group of natural products and is a xanthine oxidase inhibitor, a CYP2C9 inhibitor, and a prolyl endopeptidase inhibitor. Baicalein has antitumor, anti-inflammatory, and antibacterial activities. |
| 细胞实验 | MTT assay is conducted to evaluate the effect of baicalein on proliferation of breast cancer cells. MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×103 cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120 μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours[3]. |
| 体外活性 | 方法：人乳腺癌细胞 MDA-MB-231 用 Baicalein (0-120 µmol/L) 处理 24-72 h，使用 MTT assay 检测细胞活力。 结果：Baicalein 对 MDA-MB-231 细胞的增殖潜力具有剂量依赖性抑制作用。Baicalein 在 24、48 和 72 h 的 IC50 分别为 89.71、59.50 和 33.61 µmol/L。[1] 方法：滤泡型未分化甲状腺癌细胞 FRO 用 Baicalein (10-80 µM) 处理 36-48 h，使用 Flow cytometry 检测细胞凋亡。 结果：各剂量 Baicalein 均能显著增加 FRO 细胞的凋亡，且呈剂量依赖性。[2] |
| 体内活性 | 方法：为研究体内对肿瘤转移的影响，将 Baicalein (50-100 mg/kg) 灌胃给药人乳腺癌细胞 MDA-MB-231 的裸鼠移植模型，每天一次，持续十五天。 结果：Baicalein 在体内抑制肿瘤转移。Baicalein 在体内下调 SATB1、EMT 和 Wnt/β-catenin 通路的表达。[1] |
| 存储条件 | Store under nitrogen,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 70.7 mg/mL (261.62 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.35 mg/mL (5 mM), Solution. |
| 关键字 | XO | XanthineOxidase | Xanthine Oxidase | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | Ferroptosis | Baicalein |
| 相关产品 | Allopurinol | L-Cystine | Kaolin | Magnesium acetate tetrahydrate | Sodium Molybdate | L-Glutamic acid | Dimethyl phthalate | β-Cyclodextrin | Hemin | Imeglimin hydrochloride | Ethoxyquin | Ethyl linoleate |
| 相关库 | Anti-Cancer Approved Drug Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Flavonoid Natural Product Library | Food as Medicine Compound Library | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Cosmetic Ingredient Compound Library | Natural Product Library | Anti-virus Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Anti-Cancer Drug Library |
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文献和实验兰金 ① 度° R 开尔文 K ℃ 9/5 ℃ +32 9/5 ℃ +491.67 ℃ +273.15 ② 5/9( ℉ -32) ℉
:3993-3999) but the required Southern analysis is both time consuming and laborious. Here we demonstrate a quick and reliable method using the polymerase chain reaction (PCR) (Saiki et al. 1988 Science 239:487-491) to score the presence or absence
Quick and reliable method to analyze meiotic segregation patterns in Coprinus cinereus usi
) but the required Southern analysis is both time consuming and laborious. Here we demonstrate a quick and reliable method using the polymerase chain reaction (PCR) (Saiki et al. 1988 Science 239:487-491) to score the presence or absence of a unique insertion
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