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- CAS号：
1158347-73-9
- 规格：
1mg/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mg | 产品价格： | ￥368.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥896.0 |
| 规格： | 10mg | 产品价格： | ￥1512.0 |
| 规格： | 25mg | 产品价格： | ￥2384.0 |
| 规格： | 50mg | 产品价格： | ￥3352.0 |
| 规格： | 100mg | 产品价格： | ￥4520.0 |
| 规格： | 200mg | 产品价格： | ￥6096.0 |
Product Introduction
Bioactivity
| 名称 | VU0285655-1 |
| 描述 | VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhibitory effect on high glucose-induced caspase-3 cleavage and reduction of cell viability.VU0285655-1 is used in the study of diabetic retinopathy. |
| 体外活性 | VU0285655-1 (BML-280) (0-5 µM; 24 h; Wild-type, PLD1- and PLD2-deficient astrocytes) reduces proliferation in PLD1-deficient cells, but also in PLD2-deficient cells exposed to IGF-1. BML-280 had minor effects in wild-type and PLD2-deficient cells but completely blocked PLD activity in PLD1-deficient cells. Caused a highly significant inhibition of glial proliferation when astrocytes were stimulated by FCS (fetal calf serum) or IGF-1, respectively. Showed non-specific effects because they inhibited cell proliferation even in PLD1/2 double knockouts at 5 µM.[1] BML-280 inhibits mRNA levels and secretion of tumor necrosis factor-α, IL-1β and IL-8 in human periodontal ligament cells.[2] VU0285655-1 shows an approximately 21-fold selectivity for PLD2.[3] BML-280 (0-0.1 µM) suppresses formyl-Met-Leu-Phe (fMLP)-stimulated PLD activity in a concentration-dependent manner, with an IC50 of 0.04 ± 0.01 μM.[3] BML-280 (0-0.3 µM) inhibits O2- generation, and the inhibition reaches a plateau (about 20 % inhibition) at around 0.01 μM to 0.3 μM.[3] |
| 存储条件 | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 50 mg/mL (116.41 mM), Sonication is recommended. |
| 关键字 | 消旋-7-氧代普拉克索 | VU0285655-1 | TNF | PLD2 | Interleukin Related |
| 相关产品 | Rhamnose monohydrate | Kaolin | 1,4-Naphthoquinone | Glucosamine | Neomycin sulfate | Gum arabic | Tributyrin | Gluconate Calcium | 1,8-Cineole | Magnesium sulfate | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose |
| 相关库 | Inhibitor Library | Angiogenesis related Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Cytokine Inhibitor Library | Metabolism Compound Library | Anti-Alzheimer's Disease Compound Library | Apoptosis Compound Library | Anti-Diabetic Compound Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library |
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消旋-7-氧代普拉克索【1158347-73-9】
￥368 - 6096
