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- 2026年07月07日
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- CAS号：
286930-03-8
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥460.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥190.0 |
| 规格： | 5mg | 产品价格： | ￥396.0 |
| 规格： | 10mg | 产品价格： | ￥551.0 |
| 规格： | 25mg | 产品价格： | ￥936.0 |
| 规格： | 50mg | 产品价格： | ￥1320.0 |
| 规格： | 100mg | 产品价格： | ￥1904.0 |
| 规格： | 200mg | 产品价格： | ￥2600.0 |
Product Introduction
Bioactivity
| 名称 | Fesoterodine fumarate |
| 描述 | Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo into its active metabolite 5-hydroxymethyl tolterodine, which binds and inhibits muscarinic receptors on the bladder detrusor muscle, thereby preventing bladder contractions or spasms caused by acetylcholine. |
| 体外活性 | Fesoterodine 快速且广泛转化为 5-HMT，其药理活性主要归因于 5-HMT。[1] 在人类M1-M5细胞系中，Fesoterodine 是胆碱能激动剂刺激应答的竞争性拮抗剂，其效力和选择性概况与放射配体结合研究相似。Fesoterodine 使得carbachol的浓度-响应曲线右移，但不降低大鼠膀胱条的最大反应，并且浓度依赖性地减少电场刺激 (EFS) 引起的收缩。[2] Fesoterodine 通过非特异性酯酶水解为其活性代谢产物5-羟甲基托特罗定 (5-HMT)，5-HMT 负责Fesoterodine的所有抗胆碱能活性。[3] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.25 mM), Sonication is recommended. DMSO : 93 mg/mL (176.25 mM), Sonication is recommended. H2O : 92 mg/mL (174.36 mM), Sonication is recommended. Ethanol : 93 mg/mL (176.25 mM), Sonication is recommended. |
| 关键字 | SPM-907 | SPM907 | SPM7605 | receptor | overactive | orally | OAB | Muscarinic acetylcholine receptor | muscarinic | mAChR | Inhibitor | inhibit | Fesoterodine Fumarate | Fesoterodine | Desfesoterodine | bladder | antimuscarinic | 5-HMT |
| 相关产品 | Mitotane | Hexamethonium Bromide | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Levamisole hydrochloride | Arecoline | Choline chloride | Adenine | N,N-Dicyclohexylcarbodiimide | Propoxur | Adiphenine hydrochloride | Ribavirin |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | EMA Approved Drug Library | Neurotransmitter Receptor Compound Library | FDA-Approved Drug Library | Membrane Protein-targeted Compound Library | Anti-Neurodegenerative Disease Compound Library | Orally Active Compound Library | Drug Repurposing Compound Library | Human Metabolite Library | Toxic Compound Library |
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富马酸非索罗定【286930-03-8】
￥190 - 2600
