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- 详细信息
- 文献和实验
- 技术资料
- CAS号:
59-30-3
- 规格:
1g/1mLx10mM(inDMSO)/5g/10g/200mg/500mg
| 规格: | 1g | 产品价格: | ¥264.0 |
|---|---|---|---|
| 规格: | 1mLx10mM(inDMSO) | 产品价格: | ¥202.0 |
| 规格: | 5g | 产品价格: | ¥575.0 |
| 规格: | 10g | 产品价格: | ¥824.0 |
| 规格: | 200mg | 产品价格: | ¥122.0 |
| 规格: | 500mg | 产品价格: | ¥188.0 |
Product Introduction
Bioactivity
| 名称 | Folic acid |
| 描述 | Folic acid is an orally active essential nutrient involved in the synthesis of DNA/RNA and the production and maintenance of new cells. It exhibits antidepressant-like effects and can reduce the risk of neural tube defects in newborns. Folate deficiency can cause megaloblastic anemia, macrocytic anemia, neural tube closure defects, tumors, and aging-related diseases. Folic acid is also commonly used in research on folate deficiency-related conditions and to induce acute kidney injury models. |
| 细胞实验 | To determine the effect of FA supplementation on BRCA1 and BRCA2 mRNA expression, all cell lines were treated with 0, 25, 50, 75, or 100 nmol/L FA for 72 hours before harvesting in TRI Reagent according to the manufacturer’s instructions. (Only for Reference) |
| 体外活性 | 方法: HUVEC 细胞用 Folic acid (2.5-100 µM) 处理 48 h,使用 xCELLigence RTCA real-time cell analyzer 检测细胞增殖。 结果: Folic acid 增加了 HUVEC 细胞系中的细胞增殖,使用细胞指数确定 EC50 剂量为 50 µL。[1] 方法: 神经管外植体用 Folic acid (90 µM) 处理 3 h,使用显微镜观察形态。 结果: 在存在 Folic acid 的情况下,在 2-3 h 内,80% 的培养物中检测到细胞从神经管外植体迁移。离开初始外植体的第一个细胞是组织紧密的神经上皮细胞,并且外植体牢固地附着在纤连蛋白层上。[2] |
| 体内活性 | 方法: 为研究在抑郁症行为模型中的作用,将 Folic acid (1-100 mg/kg) 单次灌胃给药给 Swiss 小鼠,进行强迫游泳试验 (FST) 和尾部悬吊试验 (TST)。 结果: 通过口服途径给予 Folic acid 可减 少FST (50-100 mg/kg) 和 TST (10-50 mg/kg) 的不动时间。Folic acid 在 FST 和 TST 中产生抗抑郁样作用。[3] |
| 存储条件 | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.50 mg/mL (5.66 mM), Suspension. DMSO : 25.00 mg/mL (56.64 mM), Sonication is recommended. |
| 关键字 | Vitamin B-9 | Vitamin B 9 | VB9 | RNASynthesis | RNA Synthesis | nutrient | ntidepressant-like | neural tube defects | Inhibitor | inhibit | folic deficiency | Folic acid | EndogenousMetabolite | Endogenous Metabolite | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis |
| 相关产品 | Formamide | Guanidine hydrochloride | Glycerol | Aceglutamide | Malic acid | DL-Lysine | Sucrose | Nicotinamide riboside malate | Gluconate Calcium | Thymidine | Corn starch | D(+)-Raffinose pentahydrate |
| 相关库 | Anti-Cancer Approved Drug Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Miao medicine Compound Library | Gut Microbial Metabolite Library | Natural Product Library | FDA-Approved Drug Library | Tobacco Monomer Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Natural Product Library for HTS |
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文献和实验。小于6.59ng/L为缺乏。 2、红细胞叶酸含量反映体内叶酸储存情况。小于318ng/L为缺乏。 其他辅助检查:1、组氨酸负荷试验在口服组氨酸负荷剂量8h或24h后,尿中亚胺甲基谷氨酸排出量增加,但此指标特异性差,应用不普遍。 2、血浆同型半胱氨酸测定当受试者维生素B6和B12营养适宜而叶酸缺乏时同型半胱氨酸水平增高。医学教育网|搜索整理
11.2(10.0-80.0)1.59±0.341.67±0.38(0.50-2.65)135±12.0128±14.0(78.0-155)19.2±4.9317.6±4.36(13.1-29.5)2.65±0.882.62±0.87(1.00-4.30)146±1.15141±1.40(138-155)5.75±0.206.40±0.16(3.60-6.80)101±1.45105±1.22(92.0-122)24.2±3.1522.8±3.20(16.2-31.8)4.82±1.055.06±
钙代谢的负平衡,易患骨质疏松症和软骨病。铁的需要量增加,除要满足母体生理必需及贮备相当量以补偿分娩时的失血而造成的损失以外,还需要供给胎儿造血及肌肉组织所需的量。其他的无机盐如碘、镁等的需要量也增加。在缺碘地区,以妊娠期妇女及青春发育期的青少年的甲状腺肿大发病率最高,故这些人的供给量均应适当增加。 维生素的供给量也应适当增加,如维生素B1可提高孕妇食欲,促进产后乳汁分泌,并有利于分娩时子宫收缩。维生素C能增强机体的抵抗力。叶酸对于预防巨红细胞贫血、防止流产、死产、促使正常妊娠具有特别
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