Phospho-JAK3 (Tyr980/981) Poly

【产品概述】
本产品为Phospho-JAK3 (Tyr980/981) Polyclonal antibody（货号：29101-1-AP），由Rabbit / IgG宿主制备。该抗体属于Polyclonal抗体，可识别Human来源的靶蛋白，经测试适用于WB, ELISA等实验应用。产品形式为Liquid，偶联物类型为Unconjugated。

【背景介绍】
JAK3 belongs to the Janus kinase family of receptor-associated tyrosine kinases located in cytoplasm adjacent to the plasma membrane. Janus kinase family comprise four tyrosine (Tyr) kinases (JAK1, JAK2, JAK3 and Tyk2). In the cytoplasm, JAKs play a pivotal role in signal transduction via its association with type I and type II cytokine receptors, which include receptors for interleukins (ILs), interferons (IFNs), and hormones such as leptin. Interaction of a cytokine with its membrane-bound receptor complex triggers activation of receptor-bound JAKs, which phosphorylate the receptor on key cytoplasmic Tyr residues. These act as docking sites for SH2 domain-mediated interactions with STAT proteins. Receptor-bound STATs are then phosphorylated on conserved Tyr residues within their C terminal domains prior to dissociation from the receptor and formation of homo- or heterodimers. These translocate to the nucleus, bind target gene promoters, and stimulate target gene transcription. (PMID: 30948191)

【产品特点】
本抗体采用Antigen affinity purification方式纯化，确保了高特异性和批次间一致性。观测分子量约为125 kDa。推荐稀释比：WB: WB : 1:500-1:2000。Western Blot检测阳性对照组织/细胞为IL-4 treated HepG2 cells。储存缓冲液为PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.，储存条件为Store at -20°C.Aliquoting is unnecessary for -20oC storage.。Proteintech抗体经过严格的质量验证流程，确保研究人员获得可重复且可靠的实验结果。

【产品信息】
GenBank蛋白编号：BC028068；基因名称：JAK3；Gene ID (NCBI)：3718；UNIPROT ID：P52333；RRID：AB_2918234；别名包括：JAK 3, JAK3, JAK3_HUMAN, JAKL, Janus kinase 3, L JAK, Leukocyte janus kinase, LJAK, Phospho-JAK3 (Tyr980/981), Tyrosine protein kinase JAK3；免疫原为Peptide种属同源性预测；储存缓冲液为PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.，储存条件为Store at -20°C.Aliquoting is unnecessary for -20oC storage.；产品形式为Liquid；纯化方式为Antigen affinity purification。