NRF2/NFE2L2 (mouse) Polyclonal

【产品概述】
本产品为NRF2/NFE2L2 (mouse) Polyclonal antibody（货号：33123-1-AP），由Rabbit / IgG宿主制备。该抗体属于Polyclonal抗体，可识别human, mouse, rat来源的靶蛋白，经测试适用于WB, IF/ICC, ELISA等实验应用。产品形式为Liquid，偶联物类型为Unconjugated。

【背景介绍】
NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress (PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC. As new investigators break into the emerging field of Nrf2 research, confusion regarding the correct migratory pattern of Nrf2 is causing doubts about the accuracy and reproducibility of published results. This letter provides solid evidence that the actually observed molecular weight of Nrf2 is about 70kDa and 95-110 kDa. (PMID: 22703241).

【产品特点】
本抗体采用Antigen affinity Purification方式纯化，确保了高特异性和批次间一致性。观测分子量约为95-110 kDa, 75 kDa。推荐稀释比：WB: WB : 1:500-1:2000。Western Blot检测阳性对照组织/细胞为NIH/3T3 cells, NR8383 cells, rat liver tissue。储存缓冲液为PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.，储存条件为Store at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for -20oC storage.。Proteintech抗体经过严格的质量验证流程，确保研究人员获得可重复且可靠的实验结果。

【产品信息】
GenBank蛋白编号：Q60795；基因名称：Nfe2l2；Gene ID (NCBI)：18024；UNIPROT ID：Q60795；RRID：AB_3742863；别名包括：Nfe2l2, NF-E2-related factor 2, NFE2-related factor 2, Nrf2, Nuclear factor erythroid 2-related factor 2；免疫原为CatNo:Ag39859Product name: Recombinant mouse Nfe2l2 proteinSource:e coli.-derived, PGEX-4TTag: GSTDomain: 400-597 aa ofNM_010902.4Sequence: SPAQGHSAPMRESQCENTTKKEVPVSPGHQKAPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRRLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN种属同源性预测；储存缓冲液为PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.，储存条件为Store at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for -20oC storage.；产品形式为Liquid；纯化方式为Antigen affinity Purification。