- ￥386 - 4228
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- A674211
- 2026年10月27日
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- 文献和实验
- 技术资料
- 英文名：
N5-(3-(9H-Purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride
- 供应商：
上海安毕达生物科技有限公司
- CAS号：
1191385-19-9
- 规格：
1mg/5mg/10mg/25mg/50mg
| 规格： | 1mg | 产品价格： | ￥386.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥807.0 |
| 规格： | 10mg | 产品价格： | ￥969.0 |
| 规格： | 25mg | 产品价格： | ￥2421.0 |
| 规格： | 50mg | 产品价格： | ￥4228.0 |
B-Raf inhibitor 1 curtails proliferation in A375 and HCT-116 cells with IC50s of 0.31 μM and 0.72 μM, respectively. This inhibitor also connects to and maintains B-Raf in a DFG-out inactive configuration where the ATP pocket is partially occupied by Phe595 and Gly596 of the DFG motif. Moreover, B-Raf inhibitor 1 demonstrates inhibition at low micromolar concentrations in wild type B-Raf cell lines, possibly from unintended kinase effects or widespread Raf inhibition, including interactions between Raf dimers1.
B-Raf inhibitor 1 curtails proliferation in A375 and HCT-116 cells with IC50s of 0.31 μM and 0.72 μM, respectively. This inhibitor also connects to and maintains B-Raf in a DFG-out inactive configuration where the ATP pocket is partially occupied by Phe595 and Gly596 of the DFG motif. Moreover, B-Raf inhibitor 1 demonstrates inhibition at low micromolar concentrations in wild type B-Raf cell lines, possibly from unintended kinase effects or widespread Raf inhibition, including interactions between Raf dimers1.
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文献和实验MAP Kinase Regulation of the Mitotic Spindle Checkpoint
. We demonstrated that the mitogen-activated protein kinase (MAPK) cascade regulates mitotic progression and the spindle checkpoint. As demonstrated by immunofluorescence at kinetochores, depletion of Raf Kinase Inhibitory Protein (RKIP), an inhibitor of Raf/MEK/ERK
The Regulation of Tumor Suppressor Genes by Oncogenes
Tumor suppressor genes (TSGs) and oncogenes represent the ying and the yang of cell growth, differentiation, and survival control. TSGs such as p53, the retinoblastoma (RB) gene product, and the cyclin kinase inhibitor (CKI) proteins p21 Cip
14-3-3 is a potent inhibitor of protein kinase C, but the N-terminal domain does not inhibit PKC activity. Site-specific mutagenesis of several regions in the tau isoform of 14-3-3, including the mutation of a putative pseudosubstrate site
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